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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1466615
This article is part of the Research Topic The Role of Inflammation in Organ Injury View all articles

Exercise preconditioning and resveratrol reduce the susceptibility of rats with obstructive jaundice to endotoxins and alleviate lung injuries

Provisionally accepted
Xujiong Li Xujiong Li 1*Wei Li Wei Li 1Tao Wang Tao Wang 2Yan Li Yan Li 1Li Zhao Li Zhao 1*
  • 1 Department of Exercise Physiology, Beijing Sport University, Beijing, China
  • 2 Department of Pharmacy, Changzhi Medical College, Changzhi, Shanxi Province, China

The final, formatted version of the article will be published soon.

    Endotoxemia is a common issue for patients with biliary obstruction. The lung is the most affected organ by endotoxins. Exercise training can alleviate lipopolysaccharide (LPS)-induced lung inflammation and resveratrol has biological values similar to exercise. In this study, we evaluated the protective effects of exercise preconditioning, resveratrol, and their combination on LPS-induced lung injury and mortality in rats with obstructive jaundice. Endotoxemia was simulated in rats by common bile duct ligation (CBDL) and intraperitoneal injection of low-dose LPS. We found that even in the early stages, compared to sham-LPS rats, low-dose LPS induced excessive systemic inflammatory responses in CBDL rats, as evidenced by a significant increase in TNF-α and IL-6, severe lung inflammation, lung injury, and higher mortality rates, indicating that cholestasis increased rats' susceptibility to endotoxins. Exercise training reduced neutrophil infiltration in the lungs of model rats and IL-6 levels in bronchoalveolar lavage fluid. Both exercise training and resveratrol exhibited synergistic effects in reducing macrophage accumulation in lung tissues, lowering TNF-α and IL-6 levels in the lungs, and decreasing TNF-α concentration in bronchoalveolar lavage fluid. Additionally, exercise and combined interventions both significantly increased the expression of IL-10. The interventions induced a marked improvement in lung tissue pathological damage and lung edema in model rats and prolonged the survival time of rats with obstructive jaundice. Therefore, this study demonstrates that exercise preconditioning and/or resveratrol can significantly reduce rats' susceptibility to endotoxins after CBDL and alleviate lung injuries through their anti-inflammatory effects, thereby decreasing the mortality risk.

    Keywords: obstructive jaundice1, Endotoxemia2, inflammation3 lung injuries4, exercise5, resveratrol6

    Received: 18 Jul 2024; Accepted: 02 Dec 2024.

    Copyright: © 2024 Li, Li, Wang, Li and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xujiong Li, Department of Exercise Physiology, Beijing Sport University, Beijing, China
    Li Zhao, Department of Exercise Physiology, Beijing Sport University, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.