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REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1466440

The role of AIM2 in inflammation and tumors

Provisionally accepted
Da l. Yu Da l. Yu 1Si p. Zheng Si p. Zheng 2*Li n. Sui Li n. Sui 2*Yu l. Xi Yu l. Xi 2*Tian s. He Tian s. He 2*Zhi p. Liu Zhi p. Liu 2*
  • 1 Fuzhou Medical College of Nanchang University, Fuzhou, China
  • 2 Gannan Medical University, Ganzhou, China

The final, formatted version of the article will be published soon.

    Absent in melanoma 2 (AIM2) serves as an intracellular nucleic acid sensor that predominantly detects double-stranded DNA (dsDNA) within the cells. This detection initiates the assembly of inflammasome and activates the inflammasome signaling cascade, resulting in the production of inflammatory mediators and the cleavage of Gasdermins. Consequently, these processes culminate in inflammatory responses and pyroptotic cell death. AIM2 plays a pivotal role in modulating inflammation and tumorigenesis, functioning through both inflammasome-dependent and independent mechanisms. Its influence on the host immune response is dual-faceted, exhibiting both promotive and inhibitory effects in the contexts of inflammation and tumors. These effects are predominantly contingent upon the specific cell type expressing AIM2 and the nature of the host's disease. This article seeks to review the latest advancements in understanding the cell-specific functions of AIM2 in inflammation and tumorigenesis, with the objective of offering insights for further research on AIM2 and informing the development of targeted therapeutic strategies for clinical application.

    Keywords: AIM2, Inflammasome, Inflammation, tumor, cytokine

    Received: 18 Jul 2024; Accepted: 16 Oct 2024.

    Copyright: © 2024 Yu, Zheng, Sui, Xi, He and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Si p. Zheng, Gannan Medical University, Ganzhou, China
    Li n. Sui, Gannan Medical University, Ganzhou, China
    Yu l. Xi, Gannan Medical University, Ganzhou, China
    Tian s. He, Gannan Medical University, Ganzhou, China
    Zhi p. Liu, Gannan Medical University, Ganzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.