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REVIEW article

Front. Immunol.
Sec. T Cell Biology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1465006
This article is part of the Research Topic Exploring Lymphocyte Signaling: From Health to Disease View all articles

Deciphering the Impact of TERT/Telomerase on Immunosenescence and T Cell Revitalization

Provisionally accepted
Lingyi Huang Lingyi Huang 1,2*Mingfu Zhang Mingfu Zhang 3Ding Bai Ding Bai 1,2*Yi Qu Yi Qu 3*
  • 1 State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, Sichuan Province, China
  • 2 Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu, Sichuan Province, China
  • 3 Key Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Sichuan University, Chengdu, China

The final, formatted version of the article will be published soon.

    Immunosenescence impacts both the innate and adaptive immune systems, predominantly affecting certain immune cell types. A notable manifestation of immunosenescence is the diminished efficacy of adaptive immunity. The excessive senescence of immune cells, particularly T cells, leads to marked immune deficiency, consequently escalating the risk of infections, tumors, and age-associated disorders.Lymphocytes, especially T cells, are subject to both replicative and premature senescence.Telomerase reverse transcriptase (TERT) and telomerase have multifaceted roles in regulating cellular behavior, possessing the ability to counteract both replicative and premature senescence in lymphocytes. This review encapsulates recent advancements in understanding immunosenescence, with a focus on T cell senescence, and the regulatory mechanisms involving TERT/telomerase. Additionally, it comprehensively discusses strategies aimed at inhibiting immunosenescence by augmenting TERT/telomerase activity.

    Keywords: immunosenescence, Telomerase reverse transcriptase (TERT), Telomerase, CD28, T lymphocytes

    Received: 15 Jul 2024; Accepted: 02 Sep 2024.

    Copyright: © 2024 Huang, Zhang, Bai and Qu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Lingyi Huang, State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, 610041, Sichuan Province, China
    Ding Bai, Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu, 610041, Sichuan Province, China
    Yi Qu, Key Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Sichuan University, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.