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SYSTEMATIC REVIEW article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1464635

Prognostic value of neutrophil-to-lymphocyte ratio in non-muscle-invasive bladder cancer patients with intravesical Bacillus Calmette-Guérin immunotherapy: a systematic review and meta-analysis

Provisionally accepted
Jiaguo Huang Jiaguo Huang Li Lin Li Lin Dikai Mao Dikai Mao Runmiao Hua Runmiao Hua Feifei Guan Feifei Guan *
  • Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, China

The final, formatted version of the article will be published soon.

    The predictive accuracy of the preoperative neutrophil-to-lymphocyte ratio (NLR) on the prognosis of non-muscle-invasive bladder cancer (NMIBC) patients with intravesical Bacillus Calmette-Guérin immunotherapy (BCG) after transurethral resection of the bladder tumor (TURBT) remains unknown. Therefore, the current study performed a systematic review and meta-analysis to examine the relationship between preoperative NLR and the prognosis of NMIBC patients with intravesical BCG immunotherapy.Methods: For this systematic review and meta-analysis, articles were was retrieved from PubMed, the Cochrane Library, Web of Science, and Embase databases from their inception to May 14, 2024.The role of NLR in predicting recurrence and progression in NMIBC was determined using pooled hazard ratios (HRs) and 95% confidence intervals (CIs).Results: Seven articles were included in this meta-analysis, involving 4,187 patients. An elevated NLR was significantly associated with recurrence (HR=2.67, 95% CI=1.34-5.32, P<0.001) and progression (HR=1.72, 95% CI=1.13-2.60, P =0.004) in NMIBC patients with intravesical BCG immunotherapy.This meta-analysis demonstrated that elevated preoperative NLR levels were significantly associated with recurrence and disease progression in NMIBC patients who underwent intravesical BCG immunotherapy after TURBT.

    Keywords: Non-muscle-invasive bladder cancer, bacillus Calmette-Guérin, neutrophil-tolymphocyte ratio, Recurrence, progression, Systematic review, Meta-analysis (((((((((Non-Muscle Invasive Bladder Neoplasms[MeSH Terms]) OR (Non Muscle Invasive Bladder

    Received: 16 Jul 2024; Accepted: 03 Oct 2024.

    Copyright: © 2024 Huang, Lin, Mao, Hua and Guan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Feifei Guan, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, China

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