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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1462755

Coagulation-related genes for thyroid cancer prognosis, immune infltration, staging, and drug sensitivity

Provisionally accepted
Yuxiao Sun Yuxiao Sun 1Yifei Zhang Yifei Zhang 1Yuchuan Yang Yuchuan Yang 2Weihao Liu Weihao Liu 1Detao Yin Detao Yin 1,3,4*
  • 1 Department of Thyroid Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
  • 2 Department of Radiotherapy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
  • 3 Engineering Research Center of Multidisciplinary Diagnosis and Treatment of Thyroid Cancer of Henan Province, Zhengzhou, China
  • 4 Key Medicine Laboratory of Thyroid Cancer of Henan Province, Zhengzhou, China

The final, formatted version of the article will be published soon.

    Thyroid cancer (THCA) is the most common endocrine tumor. Coagulation may be associated with the development of cancer, but its role in THCA patients is not yet clear. In this study, we determined the predictive value of coagulation biomarker D-dimer for THCA patient lateral lymph node metastasis (LLNM) through receiver operating characteristics (ROC) analysis and logistic regression analysis.Subsequently, this study used the TCGA database to identify coagulation-related molecular subtypes through consensus clustering analysis and compared their prognosis. We identified coagulation-related genes (CRGs) associated with prognosis in thyroid cancer through gene expression data and clinical information, and constructed a prognostic model by selecting 8 prognostic CRGs using LASSO regression. Patients were divided into high-risk and low-risk groups. The prognosis of low-risk group patients was significantly better than that of high-risk group (P ＜ 0.001). The results showed significant differences in clinical characteristics, gene mutation occurrence, immune infiltration, function, and drug sensitivity between the high-risk and low-risk groups. We also constructed a nomogram combining the model and clinical features to predict the 3-, 5-, and 7-year survival probabilities of patients for better application of this prognostic model. We also validated by qPCR that these 8 prognostic CRGs were overexpressed in THCA cell lines. Overall, this study provided an in-depth exploration of the potential role of the coagulation in thyroid cancer and its clinical significance, offering a new theoretical basis and research direction for personalized therapy and prognostic evaluation.

    Keywords: thyroid cancer, coagulation, Prognosis signature, Immune infiltration, Clinical relevance, drug sensitivity

    Received: 10 Jul 2024; Accepted: 04 Oct 2024.

    Copyright: © 2024 Sun, Zhang, Yang, Liu and Yin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Detao Yin, Department of Thyroid Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.