Skip to main content

REVIEW article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1462505
This article is part of the Research Topic Targeting Cell Death Pathways for Cancer Immunotherapy: Specific Involve in Necroptosis, Pyroptosis, Ferroptosis, Cuproptosis, Autophagy, Apoptosis, and ICD Research View all articles

reaearch progress on ferroptosis in colorectal cancer

Provisionally accepted
Yuan Li Yuan Li 1Yao Bi Yao Bi 1Wenjing Li Wenjing Li 2Yingshi Piao Yingshi Piao 1,3Junjie PIAO Junjie PIAO 1,3Xiangshan Ren Xiangshan Ren 3,4,5,6*
  • 1 Department of Pathology & Cancer Research Center, Yanbian University Medical College, Yanji, China, yanji, China
  • 2 Department of Anesthesia, Affiliated Hospital of Yanbian University,, yanji, China
  • 3 Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Yanji, China
  • 4 Central Laboratory, Affiliated Hospital of Yanbian University, Yanji, Jilin Province, China
  • 5 Department of Pathology & Cancer Research Center, Yanbian University, Yanji, China
  • 6 Key Laboratory of Pathobiology of High Frequency Oncology in Ethnic Minority Areas (Yanbian University), State Ethnic Affairs Commission, Yanji, Jilin Province, China

The final, formatted version of the article will be published soon.

    Ferroptosis is a new form of cell death that differs from traditional forms of death. It is ferroptosisdependent lipid peroxidation death. Colorectal cancer(CRC) is the most common tumor in the gastrointestinal tract with a long occultation period and a poor five-year prognosis. Exploring effective systemic treatments for CRC remains a great challenge worldwide. Numerous studies have demonstrated that ferroptosis can participate in the biological malignant process of various tumor, including CRC, so understanding the role and regulatory mechanisms of ferroptosis in CRC plays a crucial role in the treatment of CRC. In this paper, we reviews the mechanisms of ferroptosis in CRC, the associated regulatory factors and their interactions with various immune cells in the immune microenvironment. In addition, targeting ferroptosis has emerged as an encouraging strategy for CRC treatment. Finally, to inform subsequent research and clinical diagnosis and treatment, we review therapeutic approaches to CRC radiotherapy, immunotherapy, and herbal therapy targeting ferroptosis.

    Keywords: colorectal cancer, ferroptosis, regulation, immune cell, Treatment

    Received: 10 Jul 2024; Accepted: 28 Aug 2024.

    Copyright: © 2024 Li, Bi, Li, Piao, PIAO and Ren. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiangshan Ren, Central Laboratory, Affiliated Hospital of Yanbian University, Yanji, Jilin Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.