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REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1461919
This article is part of the Research Topic Characterizing the Functional Heterogeneity of Synovial Macrophages View all articles

Advances in macrophage-myofibroblast transformation in fibrotic diseases

Provisionally accepted
Jiaqi Ban Jiaqi Ban Lihong Ao Lihong Ao Xiu He Xiu He Hua Zhao Hua Zhao Jun Li Jun Li *
  • Guizhou Medical University, Guiyang, China

The final, formatted version of the article will be published soon.

    Abstract: Macrophage-myofibroblast transformation (MMT) has emerged as a discovery in the field of fibrotic disease research. MMT is the process by which macrophages differentiate into myofibroblasts, leading to organ fibrosis following organ damage and playing an important role in fibrosis formation and progression. Recently, many new advances have been made in studying the mechanisms of MMT occurrence in fibrotic diseases. This article reviews some critical recent findings on MMT, including the origin of MMT in myofibroblasts, the specific mechanisms by which MMT develops, and the mechanisms and effects of MMT in the kidneys, lungs, heart, retina, and other fibrosis. By summarizing the latest research related to MMT, this paper provides a theoretical basis for elucidating the mechanisms of fibrosis in various organs and developing effective therapeutic targets for fibrotic diseases.

    Keywords: macrophage, Macrophage-myofibroblast transition, Fibrosis, TGF-β, myofibroblast

    Received: 10 Jul 2024; Accepted: 26 Sep 2024.

    Copyright: © 2024 Ban, Ao, He, Zhao and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jun Li, Guizhou Medical University, Guiyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.