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REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1461756
This article is part of the Research Topic Community Series in Pathogenetic mechanism and therapeutic target for inflammation in autoimmune disease: Volume II View all 3 articles

Overview of Mechanisms and novel therapies on rheumatoid arthritis from a cellular perspective

Provisionally accepted
Peng Han Peng Han 1Xiaoying Liu Xiaoying Liu 1Jiang He Jiang He 2Luyang Han Luyang Han 1Jinyao Li Jinyao Li 1*
  • 1 Xinjiang University, Urumqi, China
  • 2 Xinjiang Institute of Materia Medica, Urumqi, China

The final, formatted version of the article will be published soon.

    Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation of joints in response to autoimmune disorders. Once triggered, many factors were involved in the development of RA, including both cellular factors like osteoclasts, synovial fibroblasts, T cells, B cells, and soluble factors like interleukin-1 (IL-1), IL-6, IL-17 and tumor necrosis factor-α (TNF-α), etc. The complex interplay of those factors results in such pathological abnormality as synovial hyperplasia, bone injury and multi-joint inflammation. To treat this chronic life-affecting disease, the primary drugs used in easing the patient's symptoms are diseasemodifying antirheumatic drugs (DMARDs). However, these traditional drugs could cause serious side effects, such as high blood pressure and stomach ulcers. Interestingly, recent discoveries on the pathogenesis of RA have led to various new kinds of drugs or therapeutic strategies. Therefore, we present a timely review of the latest development in this field, focusing on the cellular aspects of RA pathogenesis and new therapeutic methods in clinical application. Hopefully it can provide translational guide to the pre-clinical research and treatment for the autoimmune joint disease.

    Keywords: Autoimmunity, Rheumatoid arthritis, therapeutic strategies, Inflammation, New treatment methods

    Received: 09 Jul 2024; Accepted: 02 Sep 2024.

    Copyright: © 2024 Han, Liu, He, Han and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jinyao Li, Xinjiang University, Urumqi, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.