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REVIEW article

Front. Immunol.
Sec. Alloimmunity and Transplantation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1461480
This article is part of the Research Topic Antibody-Mediated Rejection After Solid Organ Transplantation View all 5 articles

Application of graft-derived cell-free DNA for solid organ transplantation

Provisionally accepted
Wenqiang Zhang Wenqiang Zhang Bin Liu Bin Liu Dan Jia Dan Jia Ruiyu Wang Ruiyu Wang Hongliang Cao Hongliang Cao Hao Wu Hao Wu Zihao Ye Zihao Ye Baoshan Gao Baoshan Gao *
  • First Affiliated Hospital of Jilin University, Changchun, China

The final, formatted version of the article will be published soon.

    Monitoring the status of grafts and the occurrence of postoperative complications, such as rejection, is crucial for ensuring the success and long-term survival of organ transplants. Traditional histopathological examination, though effective, is an invasive procedure and poses risks of complications, making frequent use impractical. In recent years, graft-derived cell-free DNA (gd-cfDNA) has emerged as a promising non-invasive biomarker. It not only provides early warnings of rejection and other types of graft injury but also offers important information about the effectiveness of immunosuppressive therapy and prognosis. gd-cfDNA shows potential in the monitoring of organ transplants. The early, real-time information on graft injury provided by gd-cfDNA facilitates timely individualized treatment and improves patient outcomes. However, the progress of research on gd-cfDNA varies across different organs. Therefore, this article will comprehensively review the application and findings of gd-cfDNA in monitoring various solid organs, discussing the advantages, limitations, and some future research directions to aid in its clinical application.

    Keywords: Graft-derived cell-free DNA, gd-cfDNA, Organ Transplantation, Graft injury, rejection, Non-invasive biomarker

    Received: 08 Jul 2024; Accepted: 05 Sep 2024.

    Copyright: © 2024 Zhang, Liu, Jia, Wang, Cao, Wu, Ye and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Baoshan Gao, First Affiliated Hospital of Jilin University, Changchun, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.