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CASE REPORT article

Front. Immunol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1461024
This article is part of the Research Topic Neurological Autoimmunity: etiology, infectious complications, treatment strategies and outcomes in antibody-associated syndromes and beyond View all 19 articles

Overlapping syndrome of MOG-IgG associated optic neuritis and autoimmune encephalitis with co-existence of anti-NMDAR and anti-GABABR antibodies

Provisionally accepted
Zhujun Mei Zhujun Mei 1,2,3,4Jingguo Wang Jingguo Wang 1,2Junling Wang Junling Wang 3Xiaoni Liu Xiaoni Liu 1,2Bo Deng Bo Deng 1,2Wenbo Yang Wenbo Yang 1,2Xiang Zhang Xiang Zhang 1,2Xiangjun Chen Xiangjun Chen 1,2Hai Yu Hai Yu 1,2*
  • 1 Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China
  • 2 National Center for Neurological Disorders, Shanghai, China
  • 3 Department of Neurology, Xiangya Hospital, Central South University, Changsha, Jiangxi Province, China
  • 4 Jiangxi Provincial People's Hospital, Nanchang, Jiangxi Province, China

The final, formatted version of the article will be published soon.

    We report a case of optic neuritis (ON) secondary to autoimmune encephalitis (AE) in a patient with concomitant antibodies to N-methyl-D-aspartate receptor (NMDAR), gamma-aminobutyric acid-B receptor (GABABR), and myelin oligodendrocyte glycoprotein (MOG). The patient exhibited a constellation of symptoms, including vision loss, seizures, mental and behavioural disorders, cognitive impairment, and speech abnormalities. At the two-year follow-up, the patient's symptoms had abated entirely. Overlap syndrome of tripple autoimmune antibodies is rare and the coexistence of antibodies to NMDAR, GABABR and MOG has not been reported till now. This case report provides novel experience of diagnosis and treatment in autoimmune overlap syndromes.

    Keywords: Overlapping syndrome, autoimmune encephalitis (AE), N-methyl-D- aspartate receptor (NMDAR), Myelin oligodendrocyte glycoprotein (MOG), gamma-aminobutyric acid-B receptor (GABABR), Optic neuritis (ON)

    Received: 02 Aug 2024; Accepted: 24 Dec 2024.

    Copyright: © 2024 Mei, Wang, Wang, Liu, Deng, Yang, Zhang, Chen and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hai Yu, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China

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