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REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1460023
This article is part of the Research Topic Community Series in Targeting Signalling Pathways in Inflammatory Diseases - Volume II View all 9 articles

Understanding the Molecular Regulatory Mechanisms of Autophagy in Lung

Provisionally accepted
Lin Lin Lin Lin 1Yumeng Lin Yumeng Lin 2Zhongyu Han Zhongyu Han 3*Ke Wang Ke Wang 4Shuwei Zhou Shuwei Zhou 3Zhanzhan Wang Zhanzhan Wang 5Siyu Wang Siyu Wang 6Haoran Chen Haoran Chen 7
  • 1 Chengdu University of Traditional Chinese Medicine, Chengdu, China
  • 2 Naniing Tongren Hospital, School of Medicine, Southeast University, Nanjing, China
  • 3 School of Medicine, Southeast University, Nanjing, Jiangsu Province, China
  • 4 Hospital of Chengdu University of Traditional Chinese Medicine Deyang Hospital, Deyang, China
  • 5 Department of Respiratory and Critical Care Medicine, The First People’s Hospital of Lianyungang, Lianyungang, China
  • 6 Kunshan Hospital of Traditional Chinese Medicine Affiliated to Yangzhou University, Kunshan, China
  • 7 Affiliated Chengdu Xinhua hospital of north Sichuan medical college, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Lung disease development involves multiple cellular processes, including inflammation, cell death, and proliferation. Research increasingly indicates that autophagy and its regulatory proteins can influence inflammation, programmed cell death, cell proliferation, and innate immune responses. Autophagy plays a vital role in the maintenance of homeostasis and the adaptation of eukaryotic cells to stress by enabling the chelation, transport, and degradation of subcellular components, including proteins and organelles. This process is essential for sustaining cellular balance and ensuring the health of the mitochondrial population. Recent studies have begun to explore the connection between autophagy and the development of different lung diseases. This article reviews the latest findings on the molecular regulatory mechanisms of autophagy in lung diseases, with an emphasis on potential targeted therapies for autophagy.

    Keywords: ：autophagy, Pulmonary diseases, Apoptosis, autophagosome, COPD

    Received: 05 Jul 2024; Accepted: 07 Oct 2024.

    Copyright: © 2024 Lin, Lin, Han, Wang, Zhou, Wang, Wang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhongyu Han, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.