AUTHOR=Han Zhennan , Benlagha Kamel , Lee Pamela , Park Chan-Sik , Filatov Alexander , Byazrova Maria G. , Miller Heather , Yang Lu , Liu Chaohong TITLE=The function of serine/threonine-specific protein kinases in B cells JOURNAL=Frontiers in Immunology VOLUME=15 YEAR=2024 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1459527 DOI=10.3389/fimmu.2024.1459527 ISSN=1664-3224 ABSTRACT=

The serine/threonine-specific protein kinases (STKs) are important for cell survival, proliferation, differentiation, and apoptosis. In B cells, these kinases play indispensable roles in regulating important cellular functions. Multiple studies on human and other animal cells have shown that multiple STKs are involved in different stages of B cell development and antibody production. However, how STKs affect B cell development and function is still not completely understood. Considering that B cells are clinically important in immunity and diseases, our understanding of STKs’ roles in B cells is in great need of investigation with current technologies. Investigating serine/threonine kinases will not only deepen our insight into B cell-related disorders but also facilitate the identification of more effective drug targets for conditions like lymphoma and systemic lupus erythematosus.