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REVIEW article

Front. Immunol.
Sec. B Cell Biology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1459527
This article is part of the Research Topic Community Series in BCR Signaling and B Cell Activation: Volume 2 View all 6 articles

The Function of Serine/Threonine-specific Protein Kinases in B Cells

Provisionally accepted
Zhennan Han Zhennan Han 1Kamel Benlagha Kamel Benlagha 2Pamela Lee Pamela Lee 3Chan-Sik Park Chan-Sik Park 4Alexander Filatov Alexander Filatov 5Maria G. Byazrova Maria G. Byazrova 5Heather Miller Heather Miller 6Lu Yang Lu Yang 1*Chaohong Liu Chaohong Liu 1*
  • 1 Huazhong University of Science and Technology, Wuhan, China
  • 2 Institut de Recherche Saint Louis, Université de Paris, Paris, France
  • 3 Department of Paediatrics and Adolescent Medicine, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, SAR China
  • 4 Department of Pathology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Republic of Korea
  • 5 National Research Center Institute of Immunology, Federal Medical & Biological Agency of Russia, Moscow, Moscow Oblast, Russia
  • 6 Other, Fremont, United States

The final, formatted version of the article will be published soon.

    The serine/threonine-specific protein kinases (STKs) are important for cell survival, proliferation, differentiation, and apoptosis. In B cells, these kinases play indispensable roles in regulating important cellular functions. Multiple studies on human and other animal cells have shown that multiple STKs are involved in different stages of B cell development and antibody production. However, how STKs affect B cell development and function is still not completely understood. Considering that B cells are clinically important in immunity and diseases, our understanding of STKs' roles in B cells is in great need of investigation with current technologies. Investigating serine/threonine kinases will not only deepen our insight into B cell-related disorders but also facilitate the identification of more effective drug targets for conditions like lymphoma and systemic lupus erythematosus.

    Keywords: STK family protein, B cell, Cell Differentiation, Cell Proliferation, B cell activation

    Received: 04 Jul 2024; Accepted: 06 Sep 2024.

    Copyright: © 2024 Han, Benlagha, Lee, Park, Filatov, Byazrova, Miller, Yang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Lu Yang, Huazhong University of Science and Technology, Wuhan, China
    Chaohong Liu, Huazhong University of Science and Technology, Wuhan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.