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CASE REPORT article

Front. Immunol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1459119

Refractory Focal Motor Seizure Associated with Cerebrospinal Fluid Neurochondrin Antibody

Provisionally accepted
Rowaid Ahmad Rowaid Ahmad Yumeng Huang Yumeng Huang Peter R. Wang Peter R. Wang Todd Masel Todd Masel Xiangping Li Xiangping Li *
  • University of Texas Medical Branch at Galveston, Galveston, Texas, United States

The final, formatted version of the article will be published soon.

    The Neurochondrin-associated neurological disorder is rare and its principal clinical manifestations observed so far are cerebellar ataxia, rhombencephalitis, and hyperkinetic movements such as chorea. Neurochondrin antibody-associated Autoimmune Epilepsy (AE) has not been previously reported in the literature. This is the first reported case of refractory autoimmune epilepsy with positive CSF anti-neurochondrin antibody. This study reveals an under-recognized role of neurochondrin antibody in epilepsy.

    Keywords: Xiangping Li: Conceptualization, supervision, Writing -original draft, Writing -review & editing. Peter R Wang: Writingoriginal draft. Rowaid Ahmad: Writing -original draft. Todd Masel: Conceptualization, Writing -review & editing. Yumeng Huang: Writing -original draft Autoimmune epilepsy, Neurochondrin antibody, norbin, Autoimmune cerebellar ataxia

    Received: 05 Jul 2024; Accepted: 26 Aug 2024.

    Copyright: © 2024 Ahmad, Huang, Wang, Masel and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiangping Li, University of Texas Medical Branch at Galveston, Galveston, 77555, Texas, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.