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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1458839
This article is part of the Research Topic Allergy and autoimmune disease, two faces of the dysregulated immune system? View all articles

Distinct IgE Sensitization Profiles in Chronic Urticaria: A Comparative Study with Classic Allergic Diseases

Provisionally accepted
Xianjie Yang Xianjie Yang 1Shifei Li Shifei Li 1*Anqi Chen Anqi Chen 1*Huan Wang Huan Wang 1*Sisi Deng Sisi Deng 1*Bing Ni Bing Ni 2*Zhiqiang Song Zhiqiang Song 1*Qiquan Chen Qiquan Chen 1,2*
  • 1 Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, China
  • 2 Department of Pathophysiology, Army Medical University, Chongqing, China

The final, formatted version of the article will be published soon.

    Chronic urticaria (CU) is not traditionally classified as an allergic disease, but emerging evidence suggests a link to atopy. The quintessential marker of atopy is IgE sensitization, there is scarce information on the IgE sensitization characteristics of CU. To investigate IgE sensitization characteristics in CU, and compare them with classic allergic diseases. We retrospectively analyzed the results of specific IgE (sIgE) and total IgE (tIgE) in CU patients, explored the distribution patterns of these atopic markers in CU, and compared these data with those of atopic dermatitis (AD), allergic rhinitis (AR), asthma (AS), and healthy controls (HC). 1149 patients (396 CU, 411 AD, 101 AR, 139 AS and 102 HC) were included in the study. 33.1% of CU patients showed positive sIgE and 49.0 % had elevated tIgE levels, significantly higher than those in HC. Comparative analysis with classic allergic diseases showed CU patients had a lower sIgE positivity rate but no significant difference in tIgE levels. Gender and age influenced sensitization profiles, with male CU patients showing a higher sIgE positivity rate. The distribution of sIgE levels, allergen categories, and tIgE elevated levels range in CU differed from classic allergic disease. The concordance rate between sIgE and tIgE results in CU was lower than in classic allergic disease. Our study reveals that a significant proportion of CU patients display IgE sensitization, suggesting a clear atopic background compared to the general population.However, the IgE sensitization profile in CU differs from that of classical allergic diseases such as AD, AR, and AS, characterized by relatively lower intensity of IgE sensitization. The underlying reasons for this phenomenon and its clinical implications in CU warrant further research.

    Keywords: chronic urticaria, Atopy, IgE sensitization, allergen, allergic disease

    Received: 03 Jul 2024; Accepted: 18 Nov 2024.

    Copyright: © 2024 Yang, Li, Chen, Wang, Deng, Ni, Song and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Shifei Li, Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, 400038, China
    Anqi Chen, Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, 400038, China
    Huan Wang, Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, 400038, China
    Sisi Deng, Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, 400038, China
    Bing Ni, Department of Pathophysiology, Army Medical University, Chongqing, China
    Zhiqiang Song, Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, 400038, China
    Qiquan Chen, Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, 400038, China

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