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BRIEF RESEARCH REPORT article

Front. Immunol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1458713
This article is part of the Research Topic Aging, Peripheral Inflammation, and Neurodegeneration View all 13 articles

The associations between common neuroimaging parameters of Progressive Supranuclear Palsy in Magnetic Resonance Imaging and non-specific inflammatory factors – pilot study

Provisionally accepted
Piotr Alster Piotr Alster 1*Dagmara Otto-Ślusarczyk Dagmara Otto-Ślusarczyk 2Michał Kutyłowski Michał Kutyłowski 3Bartosz Migda Bartosz Migda 4Alicja Wiercińska-Drapało Alicja Wiercińska-Drapało 5Joanna Jabłońska Joanna Jabłońska 5Marta Struga Marta Struga 2Natalia Madetko-Alster Natalia Madetko-Alster 1
  • 1 Department of Neurology, Medical University of Warsaw, Warsaw, Masovian, Poland
  • 2 Department of Biochemistry, Medical University of Warsaw, Warsaw, Masovian, Poland
  • 3 Department of Diagnostic Imaging, Mazowiecki Hospital Brodnowski, Warsaw, Poland
  • 4 2- Diagnostic Ultrasound Lab, Department of Pediatric Radiology, Medical University of Warsaw,, Warsaw, Masovian, Poland
  • 5 Department of Infectious and Tropical Diseases and Hepatology, Medical University of Warsaw, Warsaw, Masovian, Poland

The final, formatted version of the article will be published soon.

    Progressive Supranuclear Palsy is an atypical parkinsonism based on tauopathic pathology. Growing interest is associated with the pathomechanism of this disease. Among theories analyzing this issue can be mentioned the one highlighting the significance of inflammation. In this study authors examined 14 patients with PSP-Richardson syndrome (PSP-RS) and 13 healthy volunteers using laboratory testing based on the analysis of interleukins 1 and 6 (IL-1 and IL-6), tau in the cerebrospinal fluid (CSF) and non-specific parameters of peripheral inflammation in the serum (IL-1, IL-6, neutrophils, lymphocytes, monocytes, platelets and the ratios based on the factors). All of the patients underwent neuroimaging using magnetic resonance imaging using 3 Tesla. The serum levels of IL-1 were positively correlated with the area of the mesencephalon, suggesting that higher levels of IL-1 are not linked with atrophic changes in this region, whereas serum levels IL-6 was positively correlated with frontal horn width and negatively correlated with superior cerebellar area. Additionally IL-6 in the serum was found to be correlated with neutrophil-to-high density lipoprotein ratio. The observations were not confirmed in the analysis of the levels of interleukins in the CSF. To the best of our knowledge this work is one of the first analyzing this issue. The outcome of the work shows that the role of interleukins associated with microglial activation may possibly differ in the context of neurodegenerative changes, moreover the role of peripheral inflammation in PSP requires further analysis.

    Keywords: Neuroinflammation, neurodegeneration, Psp, atypical parkinsonisms, tauopathy, Tauopathy

    Received: 02 Jul 2024; Accepted: 29 Jul 2024.

    Copyright: © 2024 Alster, Otto-Ślusarczyk, Kutyłowski, Migda, Wiercińska-Drapało, Jabłońska, Struga and Madetko-Alster. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Piotr Alster, Department of Neurology, Medical University of Warsaw, Warsaw, 00-001, Masovian, Poland

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