Skip to main content

REVIEW article

Front. Immunol.
Sec. Immunological Tolerance and Regulation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1458209

PD-1 immunology in the kidneys: A growing relationship

Provisionally accepted
Ruyue CHEN Ruyue CHEN Qiang Lin Qiang Lin *Hanyun Tang Hanyun Tang *Xiaomei Dai Xiaomei Dai *Lu Jiang Lu Jiang *Ningxun Cui Ningxun Cui *Xiaozhong Li Xiaozhong Li *
  • Children's Hospital of Soochow University, Suzhou, China

The final, formatted version of the article will be published soon.

    In recent years, knowledge regarding immune regulation has expanded rapidly, and major advancements have been made in immunotherapy for immune-associated disorders, particularly cancer. The programmed cell death 1 (PD-1) pathway is a cornerstone in immune regulation. It comprises PD-1 and its ligands mediating immune tolerance mechanisms and immune homeostasis. Accumulating evidence demonstrates that the PD-1 axis has a crucial immunosuppressive role in the tumor microenvironment and autoimmune diseases. PD-1 receptors and ligands on immune cells and renal parenchymal cells aid in maintaining immunological homeostasis in the kidneys. Here, we present a comprehensive review of PD-1 immunology in various kidney disorders, including renal cell carcinoma, glomerulonephritis, kidney transplantation, renal aging, and renal immune-related adverse events secondary to PD-1 immunotherapy.

    Keywords: Programmed death 1, Programmed death ligand 1, Renal cell carcinoma, Glomerulonephritis, Kidney Transplantation, Renal aging, Immune-related adverse events

    Received: 02 Jul 2024; Accepted: 07 Oct 2024.

    Copyright: © 2024 CHEN, Lin, Tang, Dai, Jiang, Cui and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Qiang Lin, Children's Hospital of Soochow University, Suzhou, China
    Hanyun Tang, Children's Hospital of Soochow University, Suzhou, China
    Xiaomei Dai, Children's Hospital of Soochow University, Suzhou, China
    Lu Jiang, Children's Hospital of Soochow University, Suzhou, China
    Ningxun Cui, Children's Hospital of Soochow University, Suzhou, China
    Xiaozhong Li, Children's Hospital of Soochow University, Suzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.