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CASE REPORT article
Front. Immunol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1458022
The Known and Unknown of Post-pump Chorea: Robust Steroid Responsiveness Implicates Occult Neuroinflammation
Provisionally accepted- 1 SUNY Upstate Medical University, Syracuse, United States
- 2 Johns Hopkins University, Baltimore, Maryland, United States
Post-pump chorea (PPC) is characterized by the development of choreiform movements following cardiopulmonary bypass (CPB) surgery. PPC occurs almost exclusively in children, and its pathophysiology remains unclear. Here we present an adult case of PPC after bovine aortic valve replacement (AVR) which exhibited dramatic and reproducible response to steroid, suggesting the presence of occult neuroinflammation. This observation suggests a novel underlying mechanism in certain subgroups of PPC, which is likely a heterogeneous condition to start with. Further research into the pathomechanisms of PPC could offer insights into managing this otherwise symptomatic control-only condition.
Keywords: Chorea (non-Huntington's), Post-pump chorea, Cardiopulmonary bypass (CPB), Neuroinflammation, Bioprosthetic aortic valve, Hypoxia Inducible Factor
Received: 01 Jul 2024; Accepted: 26 Aug 2024.
Copyright: © 2024 Iqbal, Zaman, Ojha, Gau and Young. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Muhammad Iqbal, SUNY Upstate Medical University, Syracuse, United States
Muizz Zaman, SUNY Upstate Medical University, Syracuse, United States
Niranjan Ojha, SUNY Upstate Medical University, Syracuse, United States
Yung-Tian A. Gau, SUNY Upstate Medical University, Syracuse, United States
Eufrosina I. Young, SUNY Upstate Medical University, Syracuse, United States
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