Skip to main content

CASE REPORT article

Front. Immunol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1458022

The Known and Unknown of Post-pump Chorea: Robust Steroid Responsiveness Implicates Occult Neuroinflammation

Provisionally accepted
Muhammad Iqbal Muhammad Iqbal 1*Muizz Zaman Muizz Zaman 1*Niranjan Ojha Niranjan Ojha 1*Yung-Tian A. Gau Yung-Tian A. Gau 1,2*Eufrosina I. Young Eufrosina I. Young 1*
  • 1 SUNY Upstate Medical University, Syracuse, United States
  • 2 Johns Hopkins University, Baltimore, Maryland, United States

The final, formatted version of the article will be published soon.

    Post-pump chorea (PPC) is characterized by the development of choreiform movements following cardiopulmonary bypass (CPB) surgery. PPC occurs almost exclusively in children, and its pathophysiology remains unclear. Here we present an adult case of PPC after bovine aortic valve replacement (AVR) which exhibited dramatic and reproducible response to steroid, suggesting the presence of occult neuroinflammation. This observation suggests a novel underlying mechanism in certain subgroups of PPC, which is likely a heterogeneous condition to start with. Further research into the pathomechanisms of PPC could offer insights into managing this otherwise symptomatic control-only condition.

    Keywords: Chorea (non-Huntington's), Post-pump chorea, Cardiopulmonary bypass (CPB), Neuroinflammation, Bioprosthetic aortic valve, Hypoxia Inducible Factor

    Received: 01 Jul 2024; Accepted: 26 Aug 2024.

    Copyright: © 2024 Iqbal, Zaman, Ojha, Gau and Young. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Muhammad Iqbal, SUNY Upstate Medical University, Syracuse, United States
    Muizz Zaman, SUNY Upstate Medical University, Syracuse, United States
    Niranjan Ojha, SUNY Upstate Medical University, Syracuse, United States
    Yung-Tian A. Gau, SUNY Upstate Medical University, Syracuse, United States
    Eufrosina I. Young, SUNY Upstate Medical University, Syracuse, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.