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CASE REPORT article

Front. Immunol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1456822

Telitacicept in combination with B-cell depletion therapy in MuSK antibody-positive myasthenia gravis: A case report and literature review

Provisionally accepted
Jia Wang Jia Wang 1Haotao zheng Haotao zheng 2Jia Wei Jia Wei 2Jiaping Wu Jiaping Wu 2Ziyang Feng Ziyang Feng 1Xueqin Chen Xueqin Chen 1Yangsicheng Liu Yangsicheng Liu 1Wenxin Qin Wenxin Qin 1Xiude Qin Xiude Qin 2*Fanxin Kong Fanxin Kong 2*
  • 1 The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, China
  • 2 Encephalopathy and Psychology Department, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China

The final, formatted version of the article will be published soon.

    Muscle-specific kinase (MuSK) myasthenia gravis (MG) is relatively rare and has a higher incidence of myasthenic crisis compared with other subtypes. However, there is still a lack of effective treatment for refractory MuSK MG. We report the case of a 70-year-old female MuSK MG patient with recurrent fluctuations who stabilized on telitacicept in combination with anti-CD20 B-cell depletion therapy. This combination regimen deserves further investigation. Furthermore, we summarized the treatment protocols of 14 previously reported cases of MuSK MG.

    Keywords: Myasthenia Gravis, Muscle-specific tyrosine kinase, Telitacicept, B-cell depletion therapy, case report

    Received: 17 Jul 2024; Accepted: 31 Oct 2024.

    Copyright: © 2024 Wang, zheng, Wei, Wu, Feng, Chen, Liu, Qin, Qin and Kong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiude Qin, Encephalopathy and Psychology Department, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China
    Fanxin Kong, Encephalopathy and Psychology Department, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China

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