AUTHOR=Liu Jin-Chuan , Zeng Qunxiong , Duan Yong-Gang , Yeung William S. B. , Li Raymond H. W. , Ng Ernest H. Y. , Cheung Ka-Wang , Zhang Qingqing , Chiu Philip C. N. 

TITLE=B cells: roles in physiology and pathology of pregnancy

JOURNAL=Frontiers in Immunology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1456171

DOI=10.3389/fimmu.2024.1456171

ISSN=1664-3224

ABSTRACT=<p>B cells constitute a diverse and adaptable immune cell population with functions that can vary according to the environment and circumstances. The involvement of B cells in pregnancy, as well as the associated molecular pathways, has yet to be investigated. This review consolidates current knowledge on B cell activities and regulation during pregnancy, with a particular focus on the roles of various B cell subsets and the effects of B cell-derived factors on pregnancy outcomes. Moreover, the review examines the significance of B cell-associated autoantibodies, cytokines, and signaling pathways in relation to pregnancy complications such as pregnancy loss, preeclampsia, and preterm birth.</p>