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REVIEW article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1455607
This article is part of the Research Topic Role and Mechanism of Regulated Cell Death in Musculoskeletal Development, Homeostasis, and Diseases View all articles
Contemporary Insights and Prospects on Ferroptosis in Rheumatoid Arthritis Management
Provisionally accepted- Inner Mongolia Medical College, Hohhot, China
Rheumatoid arthritis (RA) is a common autoimmune disease characterized primarily by persistent synovial inflammation and joint destruction. In recent years, ferroptosis, as a novel form of cell death, has garnered widespread attention due to its critical role in various diseases. This review explores the potential mechanisms of ferroptosis in RA and its relationship with the pathogenesis of RA, systematically analyzing the regulatory role of ferroptosis in synovial cells, chondrocytes, and immune cells. We emphasize the evaluation of ferroptosis-related pathways and their potential as therapeutic targets, including the development and application of inhibitors and activators. Although ferroptosis shows some promise in RA treatment, its dual role and safety issues in clinical application still require in-depth study. Future research should focus on elucidating the specific mechanisms of ferroptosis in RA pathology and developing more effective and safer therapeutic strategies to provide new treatment options for RA patients.
Keywords: Rheumatoid arthritis, ferroptosis, therapeutic targets, Lipid Peroxidation, iron metabolism, Antioxidant Defense
Received: 27 Jun 2024; Accepted: 03 Sep 2024.
Copyright: © 2024 Zhao, dong, Hua, Wu and Ao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
qiumei dong, Inner Mongolia Medical College, Hohhot, China
Hao Hua, Inner Mongolia Medical College, Hohhot, China
Hao Wu, Inner Mongolia Medical College, Hohhot, China
Limei Ao, Inner Mongolia Medical College, Hohhot, China
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