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CASE REPORT article

Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1454813

ASEPTIC ABSCESS SYNDROME: A CASE REPORT OF A PATIENT ACHIEVING REMISSION WITH BOTH INFLIXIMAB ORIGINATOR AND BIOSIMILAR ADMINISTERED AT VARIED INTERVALS

Provisionally accepted
Federica Maria Ucci Federica Maria Ucci 1*Rossana Scrivo Rossana Scrivo 1*Cristiano Alessandri Cristiano Alessandri 1Fabrizio Conti Fabrizio Conti 1Roberta Priori Roberta Priori 2
  • 1 Sapienza University of Rome, Rome, Italy
  • 2 Saint Camillus International University of Health and Medical Sciences, Rome, Lazio, Italy

The final, formatted version of the article will be published soon.

    Aseptic abscesses syndrome is a rare but increasingly recognized disease that falls within the spectrum of autoinflammatory disorders. Here, we describe the case of a patient who presented with abdominal pain and fever, along with multiple abdominal and extra-abdominal abscesses, in the absence of underlying hematologic, autoimmune, infectious, or neoplastic conditions. Initially, the patient responded to glucocorticoids, but experienced several flares upon discontinuation, leading to the initiation of treatment with a TNF inhibitor. After 5 years, an attempt to discontinue treatment resulted in a new flare of the disease. Remission was eventually achieved with a biosimilar TNF inhibitor, albeit requiring shortened infusion intervals.

    Keywords: aseptic abscess syndrome1, autoinflammatory disorder2, TNF-inhibitor, biosimilar4, non-medical switch5

    Received: 25 Jun 2024; Accepted: 11 Nov 2024.

    Copyright: © 2024 Ucci, Scrivo, Alessandri, Conti and Priori. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Federica Maria Ucci, Sapienza University of Rome, Rome, Italy
    Rossana Scrivo, Sapienza University of Rome, Rome, Italy

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