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ORIGINAL RESEARCH article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1454594
This article is part of the Research Topic New Insights into Oxidative Medicine: Unraveling the Complexity of Oxidative Stress in Health and Disease View all articles
Oxidative balance score and the potential for suffering rheumatoid arthritis: a crosssectional study
Provisionally accepted- 1 Ningbo University, Ningbo, China
- 2 Department of Urology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Liaoning Province, China
- 3 Ningbo First Hospital, Ningbo, China
- 4 School of Public Health, Health Science Center, Ningbo University, Ningbo, China
Objective: Our study is conducted to explore the link between the oxidative balance score (OBS) and rheumatoid arthritis (RA). Methods: 21,415 participants were included in our research from five cycles (2011-2012, 2013-2014, 2015-2016, 2017-2018, 2017-2020) of the National Health and Nutrition Examination Survey (NHANES). Twenty elements related to diets as well as lifestyles were combined to calculate OBS. The relationship between OBS and RA was assessed employing multivariable regression analysis. And further exploration was carried out through subgroup analysis, restricted cubic spline analysis and sensitivity analysis. Multiple covariates were selected to adjust the model for more robust results. Results: In our cross-sectional study, higher OBS has protective effect on the development of RA (OR = 0.98, 95% CI: 0.97 to 0.99). In contrast to individuals aged ≥60, the result is more prominent in the population aged 20-60 (OR = 0.97, 95% CI: 0.96 to 0.98). Marital status appears to introduce interference in the relationship between OBS and RA. And unmarried individuals exhibited different outcomes (OR = 1.02, 95% CI: 0.99 to 1.04) compared to others. The positive influence of OBS was more evident in patients with CKD and CVD, while it was stronger in individuals without diabetes and liver disease. Conclusion: A higher OBS correlates with the reduced odd of RA. Further studies are needed to shot more sights on improving dietary and lifestyles to gain proper OBS and explore whether OBS can be one of a measurement utilized to measure the risk of RA.
Keywords: Oxidative Stress, Early-onset rheumatoid arthritis, Marital Status, subgroup analysis, Nutritional impact
Received: 25 Jun 2024; Accepted: 07 Oct 2024.
Copyright: © 2024 Zhang, Yu, Fu, Zhuo, Xu, Liu, Dai and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhen Li, School of Public Health, Health Science Center, Ningbo University, Ningbo, China
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