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MINI REVIEW article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1452678
This article is part of the Research Topic The Mechanisms and Interplay of cell death in rheumatoid arthritis, lupus, and scleroderma View all 7 articles
Pathological mechanisms and crosstalk among various cell death pathways in cardiac involvement of systemic lupus erythematosus
Provisionally accepted- 1 Heart Center, The First Affiliated Hospital of Henan University of CM, Zheng Zhou, China
- 2 Henan Evidence-based Medicine Center of Chinese Medicine, The First Affiliated Hospital of Henan University of CM, Zheng Zhou, China
- 3 First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China
Systemic lupus erythematosus (SLE) is a prevalent autoimmune disease primarily characterized by the involvement of multiple systems and organs. Cardiovascular disease is the primary cause of mortality in patients with SLE, though the mechanisms underlying the increased cardiovascular risk in SLE patients remain unclear. Recent studies indicate that abnormal activation of programmed cell death (PCD) signaling and the crosstalk among various forms of cell death are critical in the immunopathogenesis of SLE. Furthermore, apoptosis, necroptosis, pyroptosis, NETosis, and ferroptosis are recognized as key cellular processes in the pathogenesis of SLE and are closely linked to cardiac involvement. This review uniquely explores the intricate crosstalk between apoptosis, necroptosis, and other cell death pathways, discussing their roles and interactions in the pathogenesis of cardiac involvement in SLE. Investigating the interplay between PCD signaling and cardiac involvement in SLE in understanding the disease's underlying mechanisms and offers opportunities for new therapeutic interventions. The integration of precision medicine and innovative strategies targeting these complex pathways holds promise for enhancing the treatment prospects of SLE with cardiac involvement.
Keywords: programmed cell death, systemic lupus erythematosus, Cardiac involvement, crosstalk, Immune dysregulation
Received: 21 Jun 2024; Accepted: 19 Aug 2024.
Copyright: © 2024 Wei, Wang, Li, Li, Yu, Li, Wang, Wang and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xinlu Wang, Heart Center, The First Affiliated Hospital of Henan University of CM, Zheng Zhou, China
Yongxia Wang, Heart Center, The First Affiliated Hospital of Henan University of CM, Zheng Zhou, China
Mingjun Zhu, Heart Center, The First Affiliated Hospital of Henan University of CM, Zheng Zhou, China
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