AUTHOR=Margiotta Riccardo Giuseppe , Sozio Emanuela , Del Ben Fabio , Beltrami Antonio Paolo , Cesselli Daniela , Comar Marco , Devito Alessandra , Fabris Martina , Curcio Francesco , Tascini Carlo , Sanguinetti Guido TITLE=Investigating the relationship between the immune response and the severity of COVID-19: a large-cohort retrospective study JOURNAL=Frontiers in Immunology VOLUME=15 YEAR=2025 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1452638 DOI=10.3389/fimmu.2024.1452638 ISSN=1664-3224