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CASE REPORT article
Front. Immunol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1451693
Acute leukoencephalopathy associated with daratumumab treatment in POEMS syndrome: a case report
Provisionally accepted- 1 University Hospital Zürich, Zurich, Switzerland
- 2 University Hospital of Basel, Basel, Basel-Stadt, Switzerland
Daratumumab, a monoclonal antibody against CD38, is increasingly used in the treatment of multiple myeloma, other hematological malignancies and autoimmune diseases. Little is known about its CNS toxicity. We present a case of a patient with POEMS syndrome (syndrome of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) who developed an acute leukoencephalopathy shortly after initiation of therapy with daratumumab.The patient presented with symptoms of headache and diffuse worsening of a pre-existing tetraparesis. MRI showed a rapidly progressive leukoencephalopathy. Extensive diagnostic evaluation revealed no specific cause, suggesting the leukoencephalopathy to be caused by daratumumab.Our report highlights a probably rare, but clinically significant adverse effect of daratumumab and underlines the necessity of raised vigilance for neurological side effects in patients treated with daratumumab.
Keywords: POEMS, Daratumumab, Rapidly progressive Leukoencephalopathy, CD38-Antibody, Toxic leukoencephlaopathy
Received: 19 Jun 2024; Accepted: 02 Sep 2024.
Copyright: © 2024 Steinegger, Nierobisch, De Vere-Tyndall, Schreiner, Roth, Kappos, Kana and Herwerth. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lukas Steinegger, University Hospital Zürich, Zurich, Switzerland
Marina Herwerth, University Hospital Zürich, Zurich, Switzerland
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