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REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1450998
Unravelling oncosis: morphological and molecular insights into a unique cell death pathway
Provisionally accepted- 1 Shenzhen University, Shenzhen, China
- 2 Department of Rehabilitation Medicine, Shenzhen Second People’s Hospital, shenzhen, China
- 3 Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Shenzhen University Medical School, shenzhen, China
- 4 Pain Department of Huazhong University of Science and Technology Union Hospital, shenzhen, China
Programmed cell death (PCD) is a fundamental biological process for maintaining cellular equilibrium and regulating development, health, and disease across all living organisms. Among the various types of PCD, apoptosis plays a pivotal role in numerous diseases, notably cancer. Cancer cells frequently develop mechanisms to evade apoptosis, increasing resistance to standard chemotherapy treatments. This resistance has prompted extensive research into alternative mechanisms of programmed cell death. One such pathway is oncosis, characterized by significant energy consumption, cell swelling, dilation of the endoplasmic reticulum, mitochondrial swelling, and nuclear chromatin aggregation. Recent research suggests that oncosis can impact conditions such as chemotherapeutic cardiotoxicity, myocardial ischemic injury, stroke, and cancer, mediated by specific oncosis-related proteins. In this review, we provide a detailed examination of the morphological and molecular features of oncosis and discuss various natural or small molecule compounds that can induce this type of cell death. Additionally, we summarize the current understanding of the molecular mechanisms underlying oncosis and its role in both normal physiology and pathological conditions. These insights aim to illuminate future research directions and propose innovative strategies for leveraging oncosis as a therapeutic tool against human diseases and cancer resistance.Apoptosis and oncosis are two primary forms of cell death, each exhibiting distinct
Keywords: oncosis, Cell Death, mechanisms, Inducer, diseases and therapies
Received: 18 Jun 2024; Accepted: 07 Aug 2024.
Copyright: © 2024 Guo, Yang, Mai, Jingrong, Luo, Zhou, Yu, Wang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Feng-Yi Mai, Pain Department of Huazhong University of Science and Technology Union Hospital, shenzhen, China
Jiao Luo, Department of Rehabilitation Medicine, Shenzhen Second People’s Hospital, shenzhen, China
Dong-Dong Yu, Department of Rehabilitation Medicine, Shenzhen Second People’s Hospital, shenzhen, China
Yu-Long Wang, Department of Rehabilitation Medicine, Shenzhen Second People’s Hospital, shenzhen, China
Chen G. Li, Pain Department of Huazhong University of Science and Technology Union Hospital, shenzhen, China
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