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ORIGINAL RESEARCH article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1450544
Causal relationships between gut microbiota, immune cell, and Henoch-Schönlein Purpura: a two-step,two-sample Mendelian randomization study
Provisionally accepted- First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Background: Regulating the immune system is a crucial measure of gut microbiota (GM) that influences the development of diseases. The causal role of GM on Henoch-Schönlein Purpura (HSP) and whether it can be mediated by immune cells is still unknown.Methods: We performed a two-sample Mendelian randomization study using an inverse variance weighted (IVW) method to examine the causal role of GM on HSP and the mediation effect of immune cells between the association of GM and HSP.Results: We demonstrated the causal relationships between 14 axas and 6 pathways with HSP. Additionally, we identified 9 immune cell characteristics associated with HSP. Importantly, through mediation MR analysis, we identified several immune cell characteristics that mediate the impact of GM on HSP. For instance, Genus_Blautia affects HSP via Monocyte (HLA DR on CD14+ CD16monocyte) and Monocyte (HLA DR on monocyte). The proportion of mediation effects further elucidated the complex dynamics between GM exposure, immune markers, and their combined impact on HSP.The study suggested a causal relationship between GM and HSP, which may be mediated by immune cells.
Keywords: HSP, Gut Microbiota, immune cell, Mendelian randomization, Genetic approaches
Received: 17 Jun 2024; Accepted: 24 Jul 2024.
Copyright: © 2024 Liang, Shi, Cui, Cui, Zhao, Wang, Shi and Tian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Huijun Shi, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Han Cui, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Yaqi Cui, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Ziwei Zhao, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Yue Wang, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Dandan Shi, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Peichao Tian, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
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