Skip to main content

ORIGINAL RESEARCH article

Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1450544

Causal relationships between gut microbiota, immune cell, and Henoch-Schönlein Purpura: a two-step,two-sample Mendelian randomization study

Provisionally accepted
Tian Liang Tian Liang Huijun Shi Huijun Shi *Han Cui Han Cui *Yaqi Cui Yaqi Cui *Ziwei Zhao Ziwei Zhao *Yue Wang Yue Wang *Dandan Shi Dandan Shi *Peichao Tian Peichao Tian *
  • First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

The final, formatted version of the article will be published soon.

    Background: Regulating the immune system is a crucial measure of gut microbiota (GM) that influences the development of diseases. The causal role of GM on Henoch-Schönlein Purpura (HSP) and whether it can be mediated by immune cells is still unknown.Methods: We performed a two-sample Mendelian randomization study using an inverse variance weighted (IVW) method to examine the causal role of GM on HSP and the mediation effect of immune cells between the association of GM and HSP.Results: We demonstrated the causal relationships between 14 axas and 6 pathways with HSP. Additionally, we identified 9 immune cell characteristics associated with HSP. Importantly, through mediation MR analysis, we identified several immune cell characteristics that mediate the impact of GM on HSP. For instance, Genus_Blautia affects HSP via Monocyte (HLA DR on CD14+ CD16monocyte) and Monocyte (HLA DR on monocyte). The proportion of mediation effects further elucidated the complex dynamics between GM exposure, immune markers, and their combined impact on HSP.The study suggested a causal relationship between GM and HSP, which may be mediated by immune cells.

    Keywords: HSP, Gut Microbiota, immune cell, Mendelian randomization, Genetic approaches

    Received: 17 Jun 2024; Accepted: 24 Jul 2024.

    Copyright: © 2024 Liang, Shi, Cui, Cui, Zhao, Wang, Shi and Tian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Huijun Shi, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
    Han Cui, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
    Yaqi Cui, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
    Ziwei Zhao, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
    Yue Wang, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
    Dandan Shi, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
    Peichao Tian, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.