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REVIEW article

Front. Immunol.
Sec. B Cell Biology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1450366

The role of B cells in the pathogenesis of type 1 diabetes

Provisionally accepted
Bing Zheng Bing Zheng 1*Quan Gong Quan Gong 1*Jixin Zhong Jixin Zhong 2*Yanan Wang Yanan Wang 1Ruihua Li Ruihua Li 1Yaxuan Huang Yaxuan Huang 1Hui Chen Hui Chen 3Hao Nie Hao Nie 1Lian LIU Lian LIU 1Xiaoting Zou Xiaoting Zou 1
  • 1 Yangtze University, Jingzhou, China
  • 2 Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
  • 3 The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei Province, China

The final, formatted version of the article will be published soon.

    Type 1 diabetes (T1D) is a metabolic disorder caused by a complete lack of insulin, primarily manifested by hyperglycemia. The mechanisms underlying the onset of T1D are complex, involving genetics, environment, and various unknown factors, leading to the infiltration of various immune components into the islets. Besides T cells, B cells are now considered important contributors to the pathogenesis of T1D, according to recent studies. In Non-Obese Diabetic(NOD) mice, the absence of B cells prevents the development of T1D, and B cell depletion can even restore the function of pancreatic β -cells, emphasizing their involvement in the development of T1D. Naturally, besides pathogenic B cells, regulatory B cells (Bregs) might have a protective function in T1D. This article examines the mechanisms behind B cell tolerance and the defects in B cell tolerance checkpoints in T1D.We explored possible functions of B cells in T1D, including the role of islet autoantibodies in T1D, TB cell interactions, and the role of Bregs in the pathogenesis of T1D. We also summarized the advances of B cell-targeted therapy, exploring new methods for intervention and treatment of T1D.

    Keywords: type 1 diabetes, B cells, T cells, regulatory B cells, Marginal

    Received: 18 Jun 2024; Accepted: 29 Nov 2024.

    Copyright: © 2024 Zheng, Gong, Zhong, Wang, Li, Huang, Chen, Nie, LIU and Zou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Bing Zheng, Yangtze University, Jingzhou, China
    Quan Gong, Yangtze University, Jingzhou, China
    Jixin Zhong, Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.