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REVIEW article

Front. Immunol.
Sec. Immunological Memory
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1449986

The role of trained immunity in sepsis

Provisionally accepted
Wenjuan Wang Wenjuan Wang Lisi Ma Lisi Ma *Bin Liu Bin Liu *Liangliang Ouyang Liangliang Ouyang *
  • Department of Clinical Laboratory, Jiujiang University Affiliated Hospital, Jiujiang, China

The final, formatted version of the article will be published soon.

    Sepsis is defined as a life-threatening organ dysfunction syndrome caused by dysregulated host response to infection, characterized by a systemic inflammatory response to infection. The use of antibiotics, fluid resuscitation, and organ support therapy has limited prognostic benefit in patients with sepsis, and its incidence is not diminishing, which is attracting increased attention in medicine. Sepsis remains one of the most debilitating and expensive illnesses. One of the main reasons of septic mortality is now understood to be disruption of immune homeostasis.Immunotherapy is revolutionizing the treatment of illnesses in which dysregulated immune responses play a significant role. This "trained immunity", which is a potent defense against infection regardless of the type of bacteria, fungus, or virus, is attributed to the discovery that the innate immune cells possess immune memory via metabolic and epigenetic reprogramming. Here we reviewed the immunotherapy of innate immune cells in sepsis, the features of trained immunity, and the relationship between trained immunity and sepsis.

    Keywords: Sepsis, Immunotherapy, innate immune cells, trained immunity, reprogramming

    Received: 16 Jun 2024; Accepted: 31 Jul 2024.

    Copyright: © 2024 Wang, Ma, Liu and Ouyang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Lisi Ma, Department of Clinical Laboratory, Jiujiang University Affiliated Hospital, Jiujiang, China
    Bin Liu, Department of Clinical Laboratory, Jiujiang University Affiliated Hospital, Jiujiang, China
    Liangliang Ouyang, Department of Clinical Laboratory, Jiujiang University Affiliated Hospital, Jiujiang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.