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MINI REVIEW article

Front. Immunol.
Sec. Parasite Immunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1449495
This article is part of the Research Topic Helminthosis: Immuno-pathology and Anthelmintic Vaccines View all articles

Roles of helminth extracellular vesicle-derived let-7 in host-parasite crosstalk

Provisionally accepted
Haoran Zhong Haoran Zhong 1Guiquan Guan Guiquan Guan 2Yamei Jin Yamei Jin 1*
  • 1 Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China
  • 2 Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province, China

The final, formatted version of the article will be published soon.

    Helminth infections are a major public health problem as they can cause long-term chronic infections in their hosts for which there is no effective vaccine. During the long-term interaction between helminths and their hosts, helminth-derived extracellular vesicles (EVs) can participate in host immunomodulatory processes by secreting bioactive molecules (BMAs). Growing data suggests that microRNAs (miRNAs) in helminth EVs have a significant impact on the host's immune system.The let-7 family is highly conserved among helminth EVs and highly homologous in the host, and its function in host-parasite crosstalk may reflect active selection for compatibility with the host miRNA machinery. In-depth studies targeting this aspect may better elucidate the mechanism of parasite-host interactions. Hence, this review summarizes the current studies on the cross-species involvement of helminth EVderived let-7 in host immune regulation and discusses the barriers to related research and potential applications of helminth EVs.

    Keywords: helminth, extracellular vesicles, microRNA, Let-7 family, host-parasite interaction

    Received: 15 Jun 2024; Accepted: 06 Sep 2024.

    Copyright: © 2024 Zhong, Guan and Jin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yamei Jin, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.