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REVIEW article
Front. Immunol.
Sec. Cytokines and Soluble Mediators in Immunity
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1449411
This article is part of the Research Topic Modulation of Immune Response in Oral Health: Current Challenges and Future Directions View all 4 articles
Advances in the research of immunomodulatory mechanism of mesenchymal stromal/stem cells on periodontal tissue regeneration
Provisionally accepted
Dezhi Zhao
1
Ruilin Yang
1
Hanxiao Wei
1*
Kang Yang
1
Yibing Yang
1*
Nuo-Xin Wang
1
Qian Zhang
2*
Fang Chen
3*
Tao Zhang
1*- 1 Laboratory of Cell Engineering, Affiliated Hospital of Zunyi Medical College, Zunyi, China
- 2 Zunyi Medical University, Zunyi, Guizhou Province, China
- 3 Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, Guizhou Province, China
Periodontal disease is a highly prevalent disease worldwide that seriously affects people's oral health, including gingivitis and periodontitis. Although the current treatment of periodontal disease can achieve good control of inflammation, it is difficult to regenerate the periodontal supporting tissues to achieve a satisfactory therapeutic effect. In recent years, due to the good tissue regeneration ability, the research on Mesenchymal stromal/stem cells (MSCs) and MSC-derived exosomes has been gradually deepened, especially its ability to interact with the microenvironment of the body in the complex immunoregulatory network, which has led to many new perspectives on the therapeutic strategies for many diseases. This paper systematically reviews the immunomodulatory (including bone immunomodulation) properties of MSCs and their role in the periodontal inflammatory microenvironment, summarizes the pathways and mechanisms by which MSCs and MSC-EVs have promoted periodontal regeneration in recent years, lists potential areas for future research, and describes the issues that should be considered in future basic research and the direction of development of "cell-free therapies" for periodontal regeneration.
Keywords: Periodontal tissue regeneration, Mesenchymal Stem Cells, Periodontitis, Alveolar Bone Loss, Immunomodulation, Inflammatory microenvironment
Received: 15 Jun 2024; Accepted: 13 Dec 2024.
Copyright: © 2024 Zhao, Yang, Wei, Yang, Yang, Wang, Zhang, Chen and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hanxiao Wei, Laboratory of Cell Engineering, Affiliated Hospital of Zunyi Medical College, Zunyi, China
Yibing Yang, Laboratory of Cell Engineering, Affiliated Hospital of Zunyi Medical College, Zunyi, China
Qian Zhang, Zunyi Medical University, Zunyi, 563000, Guizhou Province, China
Fang Chen, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, Guizhou Province, China
Tao Zhang, Laboratory of Cell Engineering, Affiliated Hospital of Zunyi Medical College, Zunyi, China
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