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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Systems Immunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1448878
This article is part of the Research Topic Hepatocellular Carcinoma: From Bench to Bedside View all 4 articles

Single-cell mitophagy patterns within the tumor microenvironment modulate intercellular communication, impacting the progression and prognosis of hepatocellular carcinoma

Provisionally accepted
Zhengyan Li Zhengyan Li *Wei Chen Wei Chen Shu Yao Shu Yao *Zuxiang Peng Zuxiang Peng *Hongming Liu Hongming Liu *Yongliang Tang Yongliang Tang *Yi Feng Yi Feng *
  • Daping Hospital, Chongqing, China

The final, formatted version of the article will be published soon.

    Hepatocellular carcinoma (HCC) is a common malignant tumor of the digestive system with a high incidence that seriously threatens patients' lives and health. However, with the rise and application of new treatments, such as immunotherapy, there are still some restrictions in the treatment and diagnosis of hepatocellular carcinoma, and the therapeutic effects on patients are not ideal. Hence, investigating the pathomechanism and identifying novel diagnostic and treatment methods are important. In this study, a comprehensive single-cell analysis of mitophagy-related genes of hepatocellular carcinoma was conducted using the non-negative matrix decomposition method. Within the mitophagy patterns, there are complex cellular communication states between hepatocellular carcinoma microenvironment cells that affect the prognosis and survival of patients. Using mitophagy-related gene classification, we predicted patient prognosis and guided treatment strategies. Our findings are expected to improve diagnosis, treatment, survival rates, and quality of life in hepatocellular carcinoma patients through targeted mitophagy intervention.

    Keywords: Hepatocellular Carcinoma, mitophagy, Tumor Microenvironment, bioinformatics, prognosis

    Received: 18 Jun 2024; Accepted: 30 Sep 2024.

    Copyright: © 2024 Li, Chen, Yao, Peng, Liu, Tang and Feng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zhengyan Li, Daping Hospital, Chongqing, China
    Shu Yao, Daping Hospital, Chongqing, China
    Zuxiang Peng, Daping Hospital, Chongqing, China
    Hongming Liu, Daping Hospital, Chongqing, China
    Yongliang Tang, Daping Hospital, Chongqing, China
    Yi Feng, Daping Hospital, Chongqing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.