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CASE REPORT article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1448875
This article is part of the Research Topic Precision Oncology in Checkpoint Immunotherapy: Leveraging Predictive Biomarkers for Personalized Treatment View all articles

Case report: Significant response of Alpha-fetoprotein-producing gastric cancer from combined chemotherapy and immunotherapy

Provisionally accepted
Da Xue Da Xue 1Zhijun Hu Zhijun Hu 2*Juan Zhang Juan Zhang 2*Zhongchuan Lv Zhongchuan Lv 2*
  • 1 Department of General Surgery, Yantai Yuhuangding Hospital, Yantai, Shandong Province, China
  • 2 Yantai Yuhuangding Hospital, Yantai, Shandong Province, China

The final, formatted version of the article will be published soon.

    Alpha-fetoprotein-producing gastric cancer (AFPGC) represents a particularly aggressive subtype of gastric carcinoma characterised by elevated rates of vascular invasion ［ 1 ］ , lymphatic dissemination, hepatic metastasis, and an unfavourable clinical outcome ［ 2 ］ .Treatment strategies for AFPGC have historically lacked specificity. Herein, a case is presented involving AFPGC in which the patient exhibited a notable response to combined anti-PD-1 antibody immunotherapy and SOX chemotherapy, potentially achieving a cure.

    Keywords: Case report，Alpha-fetoprotein-producing gastric cancer (AFPGC), tislelizumab, chemotherapy, Immunotherapy, Alpha-fetoprotein (AFP)

    Received: 14 Jun 2024; Accepted: 07 Oct 2024.

    Copyright: © 2024 Xue, Hu, Zhang and Lv. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zhijun Hu, Yantai Yuhuangding Hospital, Yantai, Shandong Province, China
    Juan Zhang, Yantai Yuhuangding Hospital, Yantai, Shandong Province, China
    Zhongchuan Lv, Yantai Yuhuangding Hospital, Yantai, Shandong Province, China

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