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REVIEW article

Front. Immunol.
Sec. Nutritional Immunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1448116
This article is part of the Research Topic Cross Talk Between Diet, Microbiome, and Cancer View all 5 articles

Obesity, dietary interventions and microbiome alterations in development and progression of prostate cancer

Provisionally accepted
Shaun Trecarten Shaun Trecarten 1Michael A Liss Michael A Liss 1Jill Hamilton-Reeves Jill Hamilton-Reeves 2John DiGiovanni John DiGiovanni 3,4*
  • 1 Department of Urology, Joe R. & Teresa Lozano Long School of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States
  • 2 Department of Urology, School of Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States
  • 3 Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas, United States
  • 4 Center for Molecular Carcinogenesis and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas, United States

The final, formatted version of the article will be published soon.

    The role of the microbiome in prostate cancer is an emerging subject of research interest. Certain lifestyle factors, such as obesity and diet, can also impact the microbiome, which has been implicated in many diseases, such as heart disease and diabetes. However, this link has yet to be explored in detail in the context of prostate cancer. The purpose of this review is to explore the cross-talk between obesity, dietary interventions, and microbiome alterations in the development and progression of prostate cancer.Recent findings: Many possible mechanisms exist linking obesity and dietary interventions to microbiome alterations and prostate cancer. The gut microbiome produces metabolites that could play a role in prostate cancer oncogenesis, including short-chain fatty acids, cholesterol derivatives, and folic acid. The microbiome also plays a pivotal role in the prostate tumor microenvironment (TME), contributing to inflammation, local tissue hypoxia, and epithelialmesenchymal transition. A bidirectional relationship exists between obesity and the microbiome, and certain diets can enact changes to the microbiome, its associated metabolites, and prostate cancer outcomes.Summary: Cross-talk exists between obesity, dietary interventions, and the role of the microbiome in the development and progression of prostate cancer. To further our understanding, future human studies in prostate cancer should investigate microbiome changes and incorporate an assessment of microbiome-derived metabolites and cellular/immune changes in the TME.

    Keywords: Cross-talk, microbiome, prostate cancer, Obesity, Diet Obesity, Diet, and role of microbiome in prostate cancer 2

    Received: 12 Jun 2024; Accepted: 06 Dec 2024.

    Copyright: © 2024 Trecarten, Liss, Hamilton-Reeves and DiGiovanni. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: John DiGiovanni, Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, 78712, Texas, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.