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REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1448012

Nasopharyngeal Carcinoma-Associated Inflammatory Cytokines: Ongoing Biomarkers

Provisionally accepted
Chuwen Liang Chuwen Liang 1,2,3,4Jun Kan Jun Kan 1,2,3,4*Jingli Wang Jingli Wang 1,2,3,4*Wei Lu Wei Lu 1,2,3,4*Xiaoyan Mo Xiaoyan Mo 1,2,3,4Bei Zhang Bei Zhang 1,2,3,4*
  • 1 Sun Yat-sen University Cancer Center (SYSUCC), Guangzhou, China
  • 2 State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center (SYSUCC), Guanghzou, Guangdong, China
  • 3 Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China
  • 4 Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China

The final, formatted version of the article will be published soon.

    Nasopharyngeal carcinoma (NPC) is a neoplasm related to inflammation; the expression of cytokines, such as CCL3, CCL4, CCL20, IL-1α, IL-1β, IL-6, IL-8, and IL-10, among others, is presumed to be associated with NPC occurrence and development. Therefore, the circulating levels of these cytokines may be potential biomarkers for assessing tumor aggressiveness, exploring cellular interactions, and monitoring tumor therapeutic responses. Numerous scholars have comprehensively explored the putative mechanisms through which these inflammatory factors affect NPC progression and therapeutic responses. Moreover, investigations have focused on elucidating the correlation between the systemic levels of these cytokines and the incidence and prognosis of NPC. This comprehensive review aims to delineate the advancements in research concerning the relationship between inflammatory factors and NPC while considering their prospective roles as novel prognostic and predictive biomarkers in the context of NPC.

    Keywords: nasopharyngeal carcinoma, Inflammation, Cytokines, Predictive factors, prognostic factors

    Received: 12 Jun 2024; Accepted: 02 Oct 2024.

    Copyright: © 2024 Liang, Kan, Wang, Lu, Mo and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jun Kan, Sun Yat-sen University Cancer Center (SYSUCC), Guangzhou, China
    Jingli Wang, Sun Yat-sen University Cancer Center (SYSUCC), Guangzhou, China
    Wei Lu, Sun Yat-sen University Cancer Center (SYSUCC), Guangzhou, China
    Bei Zhang, Sun Yat-sen University Cancer Center (SYSUCC), Guangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.