AUTHOR=Mejías-Trueba Marta , Saborido-Alconchel Abraham , Serna-Gallego Ana , Trujillo-Rodríguez María , Muñoz-Muela Esperanza , Llaves-Flores Silvia , Espinosa Nuria , Roca-Oporto Cristina , Herrero Marta , Sotomayor Cesar , López-Cortes Luis F. 

TITLE=Plasma concentrations of IL-6, MIP-1β, IP-10, and PTX-3 as predictors of the immunological response to antiretroviral treatment in people with HIV

JOURNAL=Frontiers in Immunology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1447926

DOI=10.3389/fimmu.2024.1447926

ISSN=1664-3224

ABSTRACT=<p>Despite effective antiretroviral therapy (ART), 15-30% of people with HIV experience poor CD4<sup>+</sup> T-cell recovery, termed immunologic non-responders (INR). This study aims to evaluate whether pre-ART plasma levels of interleukin-6 (IL-6), interferon gamma-induced protein-10 (IP-10), macrophage inflammatory protein-1-β (MIP-1β), and/or pentraxin-3 (PTX-3) could predict subsequent immunologic recovery. Seventy-four participants were enrolled and classified as INR and immunologic responders (IR) based on CD4<sup>+</sup>/CD8<sup>+</sup> ratio increase over 24 months after starting ART. The results showed no significant differences in cytokine levels between INR and IR. Therefore, IL-6, IP-10, MIP-1β, and PTX-3 were unsuitable as predictive markers of poor immune recovery.</p>