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MINI REVIEW article

Front. Immunol.
Sec. Cytokines and Soluble Mediators in Immunity
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1447926
This article is part of the Research Topic Reviews in HIV and STIs: 2023 View all 3 articles

Plasma concentrations of IL-6, MIP-1β, IP-10, and PTX-3 as predictors of the immunological response to antiretroviral treatment in people with HIV

Provisionally accepted
Marta Mejías Trueba Marta Mejías Trueba 1Abraham Saborido Alconchel Abraham Saborido Alconchel 2Ana Serna Gallego Ana Serna Gallego 2María Trujillo Rodríguez María Trujillo Rodríguez 2Esperanza Muñoz Muela Esperanza Muñoz Muela 2Silvia Llaves Flores Silvia Llaves Flores 2Nuria Espinosa Nuria Espinosa 2Cristina Roca Oporto Cristina Roca Oporto 2Marta Herrero Marta Herrero 2Cesar Sotomayor Cesar Sotomayor 2Luis F López Cortés Luis F López Cortés 2*
  • 1 Department of Pharmacy. Clinical Unit of Infectious Diseases, Clinical Microbiology and Parasitology. Institute of Biomedicine of Seville/Virgen del Rocio University Hospital/CSIC/University of Seville. Spain., Virgen del Rocío University Hospital, Seville, Spain
  • 2 Clinical Unit of Infectious Diseases, Clinical Microbiology and Parasitology. Institute of Biomedicine of Seville/Virgen del Rocio University Hospital/CSIC/University of Seville. Spain., Virgen del Rocío University Hospital, Seville, Spain

The final, formatted version of the article will be published soon.

    Despite effective antiretroviral therapy (ART), 15-30% of people with HIV experience poor CD4 + T-cell recovery, termed immunologic non-responders (INR). This study aims to evaluate whether pre-ART plasma levels of interleukin-6 (IL-6), interferon gamma-induced protein-10 (IP-10), macrophage inflammatory protein-1-β (MIP-1β), and/or pentraxin-3 (PTX-3) could predict subsequent immunologic recovery. Seventy-four participants were enrolled and classified as INR and immunologic responders (IR) based on CD4 + /CD8 + ratio increase over 24 months after starting ART. The results showed no significant differences in cytokine levels between INR and IR. Therefore, IL-6, IP-10, MIP-1β, and PTX-3 were unsuitable as predictive markers of poor immune recovery.

    Keywords: HIV infection, IL-6, IP-10, MIP-1β, PTX-3, Immunologic response

    Received: 12 Jun 2024; Accepted: 13 Aug 2024.

    Copyright: © 2024 Mejías Trueba, Saborido Alconchel, Serna Gallego, Trujillo Rodríguez, Muñoz Muela, Llaves Flores, Espinosa, Roca Oporto, Herrero, Sotomayor and López Cortés. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Luis F López Cortés, Clinical Unit of Infectious Diseases, Clinical Microbiology and Parasitology. Institute of Biomedicine of Seville/Virgen del Rocio University Hospital/CSIC/University of Seville. Spain., Virgen del Rocío University Hospital, Seville, 41013, Spain

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.