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MINI REVIEW article

Front. Immunol.
Sec. Alloimmunity and Transplantation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1447060
This article is part of the Research Topic Finding New Hope in Old Treatments: Repurposing Immunotherapy in Transplantation View all articles

TLR4 signalling in ischemia/reperfusion injury: a promising target for linking inflammation, oxidative stress and programmed cell death to improve organ transplantation outcomes

Provisionally accepted
Sutian Wang Sutian Wang 1Kunli Zhang Kunli Zhang 2Qiuyan Huang Qiuyan Huang 1Fanming Meng Fanming Meng 1Shoulong Deng Shoulong Deng 3*
  • 1 Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, China
  • 2 Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou, Guangdong Province, China
  • 3 Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    Transplantations represent the principal therapeutic interventions for terminal organ failure, a procedure that has salvaged myriad lives annually. Ischemia/reperfusion injury (IRI) is frequently correlated with an unfavourable prognosis and is relevant for early graft dysfunction and graft survival. IRI constitutes a complex pathological state influenced by a series of factors such as oxidative stress, metabolic stress, leukocytic infiltration, programmed cell death pathways, and inflammatory immune responses.Reducing ischemia/reperfusion injury is one of the main directions of transplantation research. Toll-like receptors (TLRs) are important pattern-recognition receptors expressed on various organs that orchestrate the immune responses upon recognizing PAMPs and DAMPs. Targeting the TLR4 signalling has recently been suggested as a promising approach for alleviating IRI by affecting inflammation, oxidative stress and programmed cell death (PCD). In this minireview, we summarize the role of TLR4 signalling in regulating inflammation, oxidative stress and PCD in organ transplantation and discuss their interactions during IRI. A detailed understanding of the multiple functions of TLR4 in IRI provides novel insights into developing therapies to improve organ transplantation outcomes.

    Keywords: Toll-like receptor 4, ischemia/reperfusion injury, organ transplantation, inflammation, oxidative stress, programmed cell death Abbreviations: TLRs, toll-like receptors, IRI, ischemia/reperfusion injury, PAMP, pathogen-related molecular pattern, DAMP, damage-associated molecular pattern, pcd, programmed cell death, LPS, lipopolysaccharide, MD-2, myeloid differentiation factor 2, NF-κB, nuclear factor kappa B

    Received: 11 Jun 2024; Accepted: 05 Jul 2024.

    Copyright: © 2024 Wang, Zhang, Huang, Meng and Deng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Shoulong Deng, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, Beijing Municipality, China

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