AUTHOR=Poveda Eva , Fitzgerald Wendy , Alonso-Domínguez Jacobo , Aguayo-Arjona José , Mariño Ana , Álvarez Hortensia , Valcarce Nieves , Pérez Alexandre , Ruiz-Mateos Ezequiel , Margolis Leonid , Lederman Michael M. , Freeman Michael L. 

TITLE=Elevated plasma levels of IP-10 and MIG are early predictors of loss of control among elite HIV controllers

JOURNAL=Frontiers in Immunology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1446730

DOI=10.3389/fimmu.2024.1446730

ISSN=1664-3224

ABSTRACT=<p>Plasma cytokine levels were quantified among 30 persons with HIV (PWH) identified as elite controllers (15 transient controllers [studied a median of 1.38 years before losing viral control] and 15 persistent controllers). Thirty antiretroviral therapy (ART)-naive PWH, 30 ART-treated PWH with undetectable viremia, and 30 HIV-uninfected controls also were studied. Higher levels of cytokines were recognized among PWH than among controls, with EC displaying the highest levels. Elevated levels of IP-10 and MIG were identified among transient controllers as predictors of the loss of viral control. These findings offer feasible biomarkers for predicting virologic outcome and loss of control in EC.</p>