Skip to main content

BRIEF RESEARCH REPORT article

Front. Immunol.
Sec. Viral Immunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1446730

Elevated plasma levels of IP-10 and MIG are early predictors of loss of control among elite HIV controllers

Provisionally accepted
Eva Poveda Eva Poveda 1*Wendy Fitzgerald Wendy Fitzgerald 2Jacobo Alonso-Domínguez Jacobo Alonso-Domínguez 1José Aguayo-Arjona José Aguayo-Arjona 3Ana Mariño Ana Mariño 4Hortensia Álvarez Díaz Hortensia Álvarez Díaz 4Nieves Valcarce Nieves Valcarce 4Alexandre Pérez Alexandre Pérez 1Ezequiel Ruiz-Mateos Ezequiel Ruiz-Mateos 5Leonid Margolis Leonid Margolis 6Michael M. Lederman Michael M. Lederman 7Michael L. Freeman Michael L. Freeman 7
  • 1 Group of Virology and Pathogenesis, Galicia Sur Health Research Institute (IIS Galicia Sur). SERGAS-UVIGO, Vigo, Spain
  • 2 Section on Intercellular Interactions, Eunice Kennedy Shriver National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, United States
  • 3 Statistics and Methodology Unit, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain
  • 4 Complexo Hospitalario Universitario de Ferrol. SERGAS, A Coruña, Spain
  • 5 Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Clinical Unit of Infectious Diseases, Microbiology and Parasitology, Sevilla, Spain
  • 6 Faculty of Natural Sciences and Medicine, Ilia State University, Tbilisi, Georgia
  • 7 Case Western Reserve University, Cleveland, United States

The final, formatted version of the article will be published soon.

    Plasma cytokine levels were quantified among 30 persons with HIV (PWH) identified as elite controllers (15 transient controllers [studied a median of 1.38 years before losing viral control] and 15 persistent controllers). Thirty antiretroviral therapy (ART)-naive PWH, 30 ART-treated PWH with undetectable viremia, and 30 HIV-uninfected controls also were studied. Higher levels of cytokines were recognized among PWH than among controls, with EC displaying the highest levels. Elevated levels of IP-10 and MIG were identified among transient controllers as predictors of the loss of viral control. These findings offer feasible biomarkers for predicting virologic outcome and loss of control in EC.

    Keywords: HIV, Elite Controllers, IP-10, MIG, functional cure

    Received: 10 Jun 2024; Accepted: 12 Aug 2024.

    Copyright: © 2024 Poveda, Fitzgerald, Alonso-Domínguez, Aguayo-Arjona, Mariño, Álvarez Díaz, Valcarce, Pérez, Ruiz-Mateos, Margolis, Lederman and Freeman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Eva Poveda, Group of Virology and Pathogenesis, Galicia Sur Health Research Institute (IIS Galicia Sur). SERGAS-UVIGO, Vigo, Spain

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.