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REVIEW article

Front. Immunol.
Sec. Molecular Innate Immunity
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1445372

Epigenetic regulation of macrophage activation in chronic obstructive pulmonary disease

Provisionally accepted
Feng Zhang Feng Zhang 1,2,3,4,5,6Yachao Cui Yachao Cui 1,2,3,4,6,7Tiejun Zhang Tiejun Zhang 1,10,6,8,9*Wenguang Yin Wenguang Yin 1,2,3,4,6,7*
  • 1 State Key Laboratory of Respiratory Diseases (SKLRD), Guangzhou, Guangdong Province, China
  • 2 National Clinical Research Center for Respiratory Diseases, Guangzhou, China
  • 3 Guangzhou Institute of Respiratory Health, Guangzhou, China
  • 4 First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China
  • 5 Guangzhou National Laboratory, guangzhou, China
  • 6 GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University, Guangzhou, Guangdong, China
  • 7 Guangzhou National Laboratory, Guangzhou, China
  • 8 The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan, Guangdong, China
  • 9 Qingyuan People's Hospital, Qingyuan, China
  • 10 Guangzhou Medical University, Guangzhou, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Macrophages in the innate immune system play a vital role in various lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), acute lung injury and pulmonary fibrosis. Macrophages involved in the process of immunity need to go through a process of activation, including changes in gene expression and cell metabolism. Epigenetic modifications are key factors of macrophage activation including DNA methylation, histone modification and non-coding RNA regulation. Understanding the role and mechanisms of epigenetic regulation of macrophage activation can provide insights into the function of macrophages in lung diseases and help identification of potential therapeutic targets. This review summarizes the latest progress in the epigenetic changes and regulation of macrophages in their development process and in normal physiological states, and the epigenetic regulation of macrophages in COPD as well as the influence of macrophage activation on COPD development.

    Keywords: COPD, macrophage, Epigenetic regulation, DNA Methylation, Histone Modifications

    Received: 07 Jun 2024; Accepted: 29 Jul 2024.

    Copyright: © 2024 Zhang, Cui, Zhang and Yin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Tiejun Zhang, GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University, Guangzhou, Guangdong, China
    Wenguang Yin, State Key Laboratory of Respiratory Diseases (SKLRD), Guangzhou, Guangdong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.