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SYSTEMATIC REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1444958

Anti-inflammatory and antioxidant activity of high concentrations of hydrogen in the lung diseases: A systematic review and Meta-analysis

Provisionally accepted
Kang Xiao Kang Xiao 1*Jianwei Liu Jianwei Liu 2*Yuxin Sun Yuxin Sun 2Shangya Chen Shangya Chen 2*Jiazi Ma Jiazi Ma 2*Mao Cao Mao Cao 2*Yong Yang Yong Yang 2*Zhifeng Pan Zhifeng Pan 2*Peng Li Peng Li 2*Zhongjun Du Zhongjun Du 2*
  • 1 China Pharmaceutical University, Nanjing, Jiangsu Province, China
  • 2 Shandong First Medical University, Tai'an, Shandong, China

The final, formatted version of the article will be published soon.

    As a small molecule, hydrogen is colorless, odorless and lightest. Many studies conducted that hydrogen can protect almost every organ, including the brain, heart muscle, liver, small intestine, and lungs. To verify whether high concentrations of hydrogen (HCH) has anti-inflammatory and antioxidant activities on respiratory system, we product a systematic review and meta-analysis. We investigated MEDLINE-PubMed, Cochrane Library, ScienceDirect, Wiley and SpringerLink database and selected in vivo studies related to the anti-inflammatory or antioxidant effects of HCH in the lung diseases which were published until September 2023. We firstly identified 437 studies and only 12 met the inclusion criteria. They all conducted in rodents. The results showed that HCH had a positive effect on the reduction of tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, IL-4, IL-8, malondialdehyde (MDA), superoxide dismutase (SOD) and reactive oxygen species (ROS); but there is no effect on IL-6, we speculated that may contribut to the test results for different body fluids and at different points in time. This meta analysis discovered the protective effects on inflammation and oxidative stress, but whether there exists more effects on reduction of inflammatory and oxidant mediators needs to be further elucidated.

    Keywords: anti-inflammatory, antioxidant, high-concentration hydrogen, metaanalysis, Respiratory System, Systematic review

    Received: 06 Jun 2024; Accepted: 30 Jul 2024.

    Copyright: © 2024 Xiao, Liu, Sun, Chen, Ma, Cao, Yang, Pan, Li and Du. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Kang Xiao, China Pharmaceutical University, Nanjing, 210009, Jiangsu Province, China
    Jianwei Liu, Shandong First Medical University, Tai'an, 271000, Shandong, China
    Shangya Chen, Shandong First Medical University, Tai'an, 271000, Shandong, China
    Jiazi Ma, Shandong First Medical University, Tai'an, 271000, Shandong, China
    Mao Cao, Shandong First Medical University, Tai'an, 271000, Shandong, China
    Yong Yang, Shandong First Medical University, Tai'an, 271000, Shandong, China
    Zhifeng Pan, Shandong First Medical University, Tai'an, 271000, Shandong, China
    Peng Li, Shandong First Medical University, Tai'an, 271000, Shandong, China
    Zhongjun Du, Shandong First Medical University, Tai'an, 271000, Shandong, China

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