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REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1444884

Immune regulation and organ damage link adiponectin to sepsis

Provisionally accepted
Lili Zhang Lili Zhang 1Yuning Lin Yuning Lin 2Zhongying Zhang Zhongying Zhang 1*Yuting Chen Yuting Chen 1Jinqing Zhong Jinqing Zhong 1
  • 1 Xiamen Humanity Hospital, Xiamen, China
  • 2 Medical Laboratory, Xiamen Humanity Hospital, Fujian Medical University, Fujian, China

The final, formatted version of the article will be published soon.

    Sepsis is a life-threatening syndrome characterized by organ dysfunction, resulting from an uncontrolled or abnormal immune response to infection, which leads to septicemia. It involves a disruption of immune homeostasis, marked by the release of Inflammatory factors and dysfunction of immune cells. Adiponectin is widely recognized as an anti-inflammatory mediator, playing a crucial role in regulating immune cell function and exerting protective effects on tissues and organs. However, the physiological role of adiponectin in septicemia remains unclear due to the condition's association with immune response dysregulation and organ damage. This study focuses on the potential relationship between adiponectin and excessive immune responses, along with organ injury in septicemia. Additionally, we investigate possible explanations for the observed discrepancies in adiponectin levels among critically ill or deceased patients compared to theoretical expectations, aiming to provide valuable insights for clinical diagnostics and therapeutic interventions in sepsis.

    Keywords: adiponectin 1, sepsis 2, Hyperinflammation 3, biomarker 4, immune cell 5

    Received: 06 Jun 2024; Accepted: 07 Nov 2024.

    Copyright: © 2024 Zhang, Lin, Zhang, Chen and Zhong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhongying Zhang, Xiamen Humanity Hospital, Xiamen, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.