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REVIEW article

Front. Immunol.
Sec. T Cell Biology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1444533
This article is part of the Research Topic The Function and Regulation of T Cell Subsets in Inflammatory Disease View all articles

Epigenetic regulation of human FOXP3+ Tregs：from homeostasis maintenance to pathogen defense

Provisionally accepted
Yi Yue Yi Yue Yuqing Ren Yuqing Ren Chunya Lu Chunya Lu Ping Li Ping Li Guojun Zhang Guojun Zhang *
  • International Medical Center, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan Province, China

The final, formatted version of the article will be published soon.

    Regulatory T cells (Tregs), characterized by the expression of Forkhead Box P3 (FOXP3), constitute a distinct subset of T cells crucial for immune regulation. Tregs can exert direct and indirect control over immune homeostasis by releasing inhibitory factors or differentiating into Th-like Treg (Th-Treg), thereby actively contributing to the prevention and treatment of autoimmune diseases. The epigenetic regulation of FOXP3, encompassing DNA methylation, histone modifications, and posttranslational modifications, governs the development and optimal suppressive function of Tregs. In addition, Tregs can also possess the ability to maintain homeostasis in diverse microenvironments through non-suppressive mechanisms. In this review, we primarily focus on elucidating the epigenetic regulation of Tregs as well as their multifaceted roles within diverse physiological contexts while looking forward to potential strategies involving augmentation or suppression of Tregs activity for disease management, particularly in light of the ongoing global COVID-19 pandemic.

    Keywords: Tregs, epigenetics, Foxp3, Immune homeostasis, tissue repair, Metabolic Regulation, Hematopoiesis, Myelofibrosis CK0804 NCT05423691 PHASE1 DLI: donor lymphocyte infusion

    Received: 05 Jun 2024; Accepted: 15 Jul 2024.

    Copyright: © 2024 Yue, Ren, Lu, Li and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Guojun Zhang, International Medical Center, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.