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REVIEW article

Front. Immunol.
Sec. Microbial Immunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1444469
This article is part of the Research Topic Genetic and Molecular Determinants in Bone Health and Diseases - Volume II View all articles

Single nucleotide polymorphisms in the development of osteomyelitis and prosthetic joint infection: A narrative review

Provisionally accepted
Jia-Qi Zhou Jia-Qi Zhou 1Zixian Liu Zixian Liu 2Guanqiao Liu Guanqiao Liu 1Ming-Cong Ding Ming-Cong Ding 2Yu Zhang Yu Zhang 3*Bin Yu Bin Yu 1*Nan Jiang Nan Jiang 1*
  • 1 Nanfang Hospital, Southern Medical University, Guangzhou, China
  • 2 Lanzhou University Second Hospital, Lanzhou, Gansu Province, China
  • 3 Guangdong Provincial People's Hospital, Guangzhou, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Currently, despite advancements in diagnostic and therapeutic modalities, osteomyelitis and prosthetic joint infection (PJI) continue to pose significant challenges for orthopaedic surgeons. These challenges are primarily attributed to the high degree of heterogeneity exhibited by these disorders, which are influenced by a combination of environmental and host factors. Recent research efforts have delved into the pathogenesis of osteomyelitis and PJI by investigating single nucleotide polymorphisms (SNPs). This review comprehensively summarizes the current evidence regarding the associations between SNPs and the predisposition to osteomyelitis and PJI across diverse populations. The findings suggest potential linkages between SNPs in genes such as IL-1, IL-6, IFN-γ, TNF-α, VDR, tPA, CTSG, COX-2, MMP1, SLC11A1, Bax, NOS2, and NLRP3 with the development of osteomyelitis. Furthermore, SNPs in genes like IL-1, IL-6, TNF-α, MBL, OPG, RANK, and GCSFR are implicated in susceptibility to PJI. However, it is noted that most of these studies are single-center reports, lacking in-depth mechanistic research. To gain a more profound understanding of the roles played by various SNPs in the development of osteomyelitis and PJI, future multi-center studies and fundamental investigations are deemed necessary.

    Keywords: Osteomyelitis, Prosthetic joint infection, Single nucleotide polymorphisms, Single nucle otide variations, Narrative review

    Received: 05 Jun 2024; Accepted: 08 Aug 2024.

    Copyright: © 2024 Zhou, Liu, Liu, Ding, Zhang, Yu and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yu Zhang, Guangdong Provincial People's Hospital, Guangzhou, 510317, Guangdong Province, China
    Bin Yu, Nanfang Hospital, Southern Medical University, Guangzhou, China
    Nan Jiang, Nanfang Hospital, Southern Medical University, Guangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.