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REVIEW article
Front. Immunol.
Sec. Systems Immunology
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1444253
Liquid-liquid phase separation: A new perspective on respiratory diseases
Provisionally accepted- 1 Other, Department of Respiratory and Critical Care Medicine, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China
- 2 Department of Respiratory and Critical Care Medicine, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China
- 3 Shanghai East Hospital of Clinical Medical College, Nanjing Medical University, Shanghai, China
Liquid-liquid phase separation (LLPS) is integral to various biological processes, facilitating signal transduction by creating a condensed, membrane-less environment that plays crucial roles in diverse physiological and pathological processes. Recent evidence has underscored the significance of LLPS in human health and disease. However, its implications in respiratory diseases remain poorly understood. This review explores current insights into the mechanisms and biological roles of LLPS, focusing particularly on its relevance to respiratory diseases, aiming to deepen our understanding and propose a new paradigm for studying phase separation in this context.
Keywords: Liquid-liquid phase separation, membrane-less organelle, biomolecular condensates, Respiratory diseases, Lung
Received: 05 Jun 2024; Accepted: 09 Sep 2024.
Copyright: © 2024 Wang, Wang, Ke, Wang, Guo, Zhang, Zhang, Guo and Wan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhongliang Guo, Shanghai East Hospital of Clinical Medical College, Nanjing Medical University, Shanghai, China
Bing Wan, Department of Respiratory and Critical Care Medicine, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China
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