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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Microbial Immunology
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1443468
This article is part of the Research Topic Microbiome: The Modulator of Human Health View all articles

Risk factor assessment and microbiome analysis in peritoneal dialysis-related peritonitis reveal etiological characteristics

Provisionally accepted
Li Zhang Li Zhang 1Hongrui Zhang Hongrui Zhang 1Sensen Su Sensen Su 1Ye Jia Ye Jia 1Chenyang Liang Chenyang Liang 1Yuan Fang Yuan Fang 2Dengwei Hong Dengwei Hong 2Tianyu Li Tianyu Li 2Fuzhe Ma Fuzhe Ma 1*
  • 1 First Affiliated Hospital of Jilin University, Changchun, China
  • 2 Genoxor Medical Science and Technology Inc., Shanghai, China, Shanghai, China

The final, formatted version of the article will be published soon.

    Background: Peritoneal dialysis-related peritonitis (PDRP) is one of the most common complications of peritoneal dialysis (PD). Understanding the risk factors and etiological characteristics is indispensable for infection prevention and improving the outcome and life quality. Methods: Seventy PD patients were separated into the PDRP group (n=25) and the control group (n=45). Variables, including gender, age, body mass index, primary diseases, and history of basic diseases in the two groups, were analyzed to assess the risk factors of PDRP. Metagenomic next-generation sequencing (mNGS) and microbial culture were compared in detecting pathogenic microorganisms. Gut microbiota analysis was performed in 35 PDRP patients based on mNGS data. Results: Dialysis time and times of dialysate change were the risk factors of PDRP, and times of dialysate change was the independent risk factor of PDRP (p=0.046). mNGS produced higher sensitivity (65.79%) than microbial culture (36.84%) in identifying pathogenic microorganisms. S. aureus and K. pneumoniae (four cases) were the most frequent pathogens causing PDRP, followed by S. capitis (three cases). β diversity of the gut microbiota was significantly different between patients with fewer times of dialysate change (≤4) and more (>5), as well as between patients with gram-positive (G+) bacterial and gram-negative (G-) bacterial infection. Conclusion: The dialysis time and times of dialysate changes are not only risk factors for peritonitis in PD patients, but also stimulate significant changes in the gut microbiome structure in PDRP patients. These findings may provide a novel viewpoint for the management of patients with PDRP.

    Keywords: Peritoneal dialysis-related peritonitis, risk factor, MNGs, Pathogenic identification, gut microbiome

    Received: 04 Jun 2024; Accepted: 18 Oct 2024.

    Copyright: © 2024 Zhang, Zhang, Su, Jia, Liang, Fang, Hong, Li and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Fuzhe Ma, First Affiliated Hospital of Jilin University, Changchun, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.