Haoyan Yang
*
Lin Du
*The final, formatted version of the article will be published soon.
REVIEW article
Front. Immunol.
Sec. Vaccines and Molecular Therapeutics
Volume 15 - 2024 |
doi: 10.3389/fimmu.2024.1440935
From pathogenesis to antigens: the key to shaping the future of TB vaccines
Provisionally accepted- Beijing Zhifei Lvzhu Biopharmaceutical Co Ltd, Beijing, China
Tuberculosis (TB) remains one of the gravest global health challenges. Mycobacterium tuberculosis (M. tuberculosis), the causative agent, employs sophisticated immune evasion and pathogenesis strategies. Its capability to thrive within immune cells and incite robust inflammatory responses prolongs infection and dissemination. Mycobacterial advanced adaptations facilitate navigation through the human immune system and present a variable antigenic profile throughout different infection stages. Investigating these strategies unfolds targeted approaches to effective vaccine development against TB. This review delves into the most advanced and exhaustive insights into the immune evasion tactics and pathogenic processes of M. tuberculosis across various infection stages. The knowledge distilled from this analysis holds the promise of guiding the creation of innovative TB vaccines and translating theoretical groundwork into practical immunological defenses.
Keywords: Tuberculosis, M. tuberculosis, Pathogenesis, Immune Evasion, Vaccine
Received: 30 May 2024; Accepted: 04 Jul 2024.
Copyright: © 2024 Yang, Lei, Chai, Su and Du. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Haoyan Yang, Beijing Zhifei Lvzhu Biopharmaceutical Co Ltd, Beijing, China
Xinkui Lei, Beijing Zhifei Lvzhu Biopharmaceutical Co Ltd, Beijing, China
Siyu Chai, Beijing Zhifei Lvzhu Biopharmaceutical Co Ltd, Beijing, China
Guimin Su, Beijing Zhifei Lvzhu Biopharmaceutical Co Ltd, Beijing, China
Lin Du, Beijing Zhifei Lvzhu Biopharmaceutical Co Ltd, Beijing, China
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