- 1Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan, Hubei, China
- 2Department of Cardiology, Renmin Hospital of Wuhan University, Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, Hubei, China
- 3Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
Background: The advent of immunotherapy has changed the landscape of SCLC treatment, although the identification of reliable prognostic biomarkers remains a formidable challenge. Our objective was to investigate the prognostic implications of obesity and body composition in SCLC immunotherapy while seeking a straightforward anthropometric measure.
Methods: This retrospective study analyzed data from patients with SCLC who underwent immunotherapy between 2019 and 2023. Body composition and waist circumference (WC) were analyzed using 3D slicer software on baseline CT images. Quantitative measures, including skeletal muscle index (SMI), total adipose tissue index (TATI), and other indicators at the L3 level, along with body shape index (BSI) and additional indicators based on WC, were obtained. The relationships between these indicators, response, PFS, OS, and their interconnections were examined.
Results: A total of 145 SCLC patients who received immunotherapy were identified, of whom 133 met the inclusion criteria. In univariate analysis, a BMI≥28 kg/m2 was associated with a PFS advantage (HR 0.42, p=0.04), but this trend vanished in multivariate analysis. Body measurements exhibited stronger correlations with adipose tissue content, with BSI showing the highest correlation with muscle. In multivariate analysis, lower BSI was associated with poorer OS (HR 1.79, p=0.02). The association between muscle composition and prognosis was robust in univariate analysis but dissipated in multivariate analysis. However, accounting for a high TATI background significantly heightened the adverse effect of SMI on prognosis in the multivariate model.
Conclusion: No clear association between BMI and SCLC immunotherapy prognosis was observed. However, high adiposity exacerbated the adverse effects of sarcopenia in SCLC immunotherapy, and BSI demonstrated potential as a straightforward prognostic measure.
1 Introduction
Small cell lung cancer (SCLC) represents a neuroendocrine tumor, comprising approximately 13%-15% of all lung cancers, and remains one of the most lethal malignancies. It is highly aggressive with a poor prognosis, and over 60% of patients are diagnosed in the extensive stage (1). Etoposide plus platinum is the standard treatment for SCLC. In the chemotherapy era, the median survival for SCLC was a mere 7 months, with a 2-year survival rate of 7-8% (2). Since 2019, immune checkpoint inhibitors (ICIs) have gained approval as the first-line treatment for extensive-stage small cell lung cancer (ES-SCLC). Although the addition of ICIs has significantly extended survival in SCLC patients, these improvements are underwhelming compared to those seen in non-small cell lung cancer (NSCLC), with ICIs extending median overall survival (OS) in SCLC by only 2-4.5 months (3). Nevertheless, there has been a notable increase in the number of patients surviving beyond 3 years compared to the chemotherapy (4). Identifying potential beneficiaries of ICIs in SCLC and intervening to enhance their benefits remain pressing challenges.
Recently, contrary to the adverse effects of obesity on tumor progression in many preclinical studies, several studies have suggested that obese or high body mass index (BMI) cancer patients may derive greater benefits from ICIs, which is called the “obesity paradox” (5). Research indicates that overweight and obese NSCLC patients undergoing ICIs exhibit better progression-free survival (PFS) and OS than their non-obese counterparts, with a more pronounced trend in patients expressing positive programmed cell death ligand-1 (PD-L1) (6). Similar trends have been observed in malignant melanoma (7, 8). However, some studies have failed to establish a link between BMI and the prognosis of immunotherapy (9, 10), highlighting BMI’s limitations as a measure that doesn’t capture specific body composition. Moreover, whether BMI is associated with the prognosis of immunotherapy for SCLC remains unexplored.
In recent years, there has been significant interest in obtaining specific body composition through computed tomography (CT) images. Multiple studies have highlighted the association between subcutaneous or visceral adipose tissue and the prognosis of immunotherapy (11, 12). Additionally, the evaluation of skeletal muscle at the L3 level is a well-established method for assessing sarcopenia (13). Chaunzwa et al. studied the impact of L3 level skeletal muscle and adipose tissue composition on the prognosis of advanced NSCLC immunotherapy using CT imaging, and found that a reduction in skeletal muscle content and an increase in the density of subcutaneous adipose tissue (SAT) were associated with worse prognosis (14). There are also some small-sample studies that have shown that CT-measured reductions in skeletal muscle are detrimental to the prognosis of immunotherapy for advanced NSCLC (15, 16). However, research into immunotherapy for SCLC is still quite scarce in this field. This study aims to investigate the correlation between body composition, as determined through CT imaging, and immunotherapy prognosis in ES-SCLC. In consideration of practical applicability, we have also incorporated new anthropometric indicators based on waist circumference (WC) with the hope of identifying a more suitable indicator than BMI to guide the management of ES-SCLC patients.
2 Methods
2.1 Patient population
We conducted a retrospective analysis of 145 patients with SCLC who underwent immune checkpoint inhibitor (ICI) therapy at Zhongnan Hospital of Wuhan University from April 2019 to April 2023. Inclusion criteria comprised pathologically confirmed SCLC, CT-confirmed extensive-stage disease, receipt of at least one anti-programmed cell death protein 1 (PD-1) or anti-PD-L1 treatment, and the availability of abdominal CT or positron emission tomography/computed tomography (PET/CT) within two months before or after the first immunotherapy. Exclusion criteria included lung adenocarcinoma transformation into small cell lung cancer (n=3), unknown baseline time of immunotherapy (n=7), and loss of follow-up (n=2). Ultimately, 133 patients were included in the study.
Clinical information, including gender, age, height, weight, Eastern Cooperative Oncology Group performance status (ECOG PS), stage, metastatic organs, ICI types, and previous treatment, was collected from electronic medical records. Response, PFS, and OS were obtained through electronic medical records and telephone follow-up. Response was evaluated based on RECIST V.1.1, with a patient considered to have achieved a response if they attained complete response (CR) or partial response (PR). Our study included 4 patients who achieved CR, while efficacy evaluation was not available for 11 patients. PFS was defined as the time from the treatment start to progression or death. OS was defined as the time from the treatment start to death or last follow-up.
2.2 Measurement of WC and body composition
Analysis of non-contrasted PET-CT or CT images was performed using 3D slicer (USA, Version 5.0.2) (17). The entire image file was uploaded to the software, and the L3-L4 level of the CT image was determined (Figure 1). Muscle tissue was defined with a threshold of -29 to +150 HU, SAT with a threshold of -190 to -30 HU, and visceral adipose tissue (VAT) with a threshold of -150 to -50 HU. Two researchers, trained in imaging, independently mapped each patient’s body composition at the L3 level and WC at the L3-L4 disc level. The area of each section and skeletal muscle density (SMD) were computed using the Segment Geometry plugin (18). Every image is verified by professional radiologist.
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Figure 1. Representative imaging contour results. Yellow = SAT, Red = VAT, Blue = muscle. (A) Waist circumference measurement, the red line represents the waist circumference. (B) Representative low SMI + high TATI. (C) Representative high SMI + low TATI. SAT, subcutaneous adipose tissue; VAT, visceral adipose tissue; SMI, skeletal muscle index; TATI, total adipose tissue index.
2.3 Determination of the cut-off value
BMI is calculated as weight (kg)/height (m)². To address variations in body shape specific to Asians and Caucasians (19), we adopted Chinese adult classifications: Normal < 24 kg/m², 24 kg/m² ≤ Overweight < 28 kg/m², and Obese ≥ 28 kg/m². WC is considered a superior indicator of central obesity, with high WC defined as ≥ 0.9m for males and ≥ 0.8m for females (20). Waist-to-Height Ratio (WHtR), representing the ratio of WC to height, is considered high when WHtR > 0.5. Other novel anthropometric indicators, namely Relative Fat Mass Index (RFM), Body Shape Index (BSI), Body Roundness Index (BRI), and Weight-Adjusted-Waist Index (WWI), provide a more nuanced reflection of body fat and total fat mass distribution (21). As there are no established reference boundaries for Asians presently, we classified them into quartiles (refer to Supplementary Table S1 for formulas and boundary values).
Skeletal Muscle Index (SMI) is computed as muscle area (cm²)/height (m)². According to the international consensus on sarcopenia diagnosis (13), SMI<55 cm²/m² for males and SMI<39 cm²/m² for females defines sarcopenia. SMD, a measure of muscle attenuation associated with myosteatosis, was classified using quartiles. Skeletal Muscle Gauge (SMG), a composite index integrating SMI and SMD, is calculated as SMI multiplied by SMD and considered low when SMG<1475, as per Shachar et al.’s study (22, 23), Lean Body Mass (LBM) is estimated using the L3 muscle area (24), while VAT Index (VATi) and SAT Index (SATi) are standardized VAT and SAT areas, respectively, and Total Adipose Tissue Index (TATI) is the sum of VAT Index and SAT Index, all classified by quartiles.
2.4 Statistical analysis
Continuous variables were compared between groups using the student-t test or Mann-Whitney U test, and categorical variables were compared using the χ² test. PFS and OS were assessed using the Kaplan-Meier (KM) method, with group comparisons performed using the log-rank test. Univariate and multivariate Cox regression models were employed to estimate associations between BMI, anthropometric measures, and body composition with survival, adjusting for covariates such as age, gender, stage, ICI line, and ICI types. Logistic regression models were established to evaluate the association between each index and response incidence. Spearman correlation analysis was used to assess the correlation between various indicators. Interactions between TATI with SMI and SMG were calculated following Källberg et al.’s method (25). The main criterion for determining whether there is an interaction is based on the p-value and confidence interval (CI) of the interaction term (SMG×TATI or SMI×TATI), and stratified analysis was conducted in the multivariate model to control for variables. Statistical analyses were carried out using R V.4.2.2.
3 Results
3.1 Patient characteristics
A total of 133 patients were included in the analysis (Table 1), with the last follow-up date on October 1, 2023, and a median follow-up time of 552 days. At the last follow-up, 48 patients were still alive. The median PFS was 169 days, and the median OS was 331 days. Of the total, 62 patients achieved CR or PR, resulting in an Overall Response Rate (ORR) of 50.82%. The median time from baseline CT to immunotherapy initiation was 8 (IQR 4-24) days.
Patients had a median age of 64, with a majority being male (85.7%). The majority of patients were classified as stage IV (84.2%) based on TNM staging, and overall health was generally favorable. Chemo-immunotherapy was the predominant first-line treatment (69.9%), with a similar distribution between anti-PD-1 and anti-PD-L1 treatments. Sarcopenia was prevalent at baseline, affecting 70.7% of patients, with higher incidence observed in those with normal and overweight BMI compared to obese individuals.
3.2 Associations with BMI
We utilized the KM method to analyze survival differences among BMI subgroups (Supplementary Figure S1). Overall, no significant differences were observed in PFS and OS among the subgroups. However, in pairwise comparisons, PFS was significantly better in the obese group compared to the overweight group (p-value=0.04). In univariate analysis, the response in the overweight group was significantly worse than the normal group (OR 0.43, 95% CI 0.18 to 0.95, p-value=0.04), and the PFS in the obese group was significantly better than the overweight group (HR 0.42, 95% CI 0.19 to 0.96, p-value=0.04). However, these differences were not significant in multivariate analysis (Supplementary Table S2).
3.3 Correlation between each indicator
Given the inclusion of numerous anthropometric indicators, in addition to commonly used BMI, in this study, other indicators also show potential for clinical application. We aimed to explore the correlation between these indicators and body composition (Figure 2). After excluding indicators with direct calculation relations, we observed that all anthropometric measures, including BMI, were strongly associated with adipose composition and weakly associated with muscle composition. The anthropometric indicator with the strongest correlation with muscle tissue is BSI, with a correlation coefficient of 0.50 with SMI and 0.65 with LBM. Additionally, BSI maintains a strong correlation with TATI (correlation coefficient 0.71).
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Figure 2. The heatmap showing the correlation between various anthropometric indicators and body composition. The numbers in the chart represent the correlation coefficient. A correlation coefficient>0.7 is considered a strong correlation, while 0.3<correlation coefficient ≤ 0.7 is considered a moderate correlation, and correlation coefficient<0.3 is considered a weak correlation. BMI, body mass index; WC, waist circumference; WHtR, waist-to-height ratio; RFM, relative fat mass index; BSI, body shape index; BRI, body roundness index; WWI, weight-adjusted-waist index; SMI, skeletal muscle index; SMD, skeletal muscle density; SMG, skeletal muscle gauge; TATI, total adipose tissue index; VATi, visceral adipose tissue index; SATi, subcutaneous adipose tissue index; VSR, visceral to subcutaneous adipose tissue area ratio; LBM, lean body mass.
3.4 Associations with anthropometric measures
As the clinical significance of new anthropometric indicators in cancer prognosis remains unclear, univariate and multivariate analyses were conducted with high quartile and low quartile as cut-off values, in addition to WC and WHtR. In univariate analysis, no significant associations were found between anthropometric measures and response, PFS, or OS. However, after adjusting for covariates, a poorer response was observed in patients with a lower WWI (OR 0.34, 95% CI 0.11 to 0.97, p-value=0.047), and a poorer OS was observed in patients with a lower BSI (HR 1.79, 95% CI 1.09 to 2.94, p-value=0.02) (Supplementary Table S3).
3.5 Associations with body composition measures
In univariate analysis, lower SMI and SMG were associated with worse response (SMI: OR 0.35, 95% CI 0.15 to 0.76, p-value=0.01; SMG: OR 0.4, 95% CI 0.18 to 0.84, p-value=0.02) and OS (SMI: HR 2.00, 95% CI 1.20 to 3.34, p-value=0.01; SMG: HR 1.63, 95% CI 1.06 to 2.51, p-value=0.03), and lower SMG was also associated with worse PFS (HR 1.73, 95% CI 1.18 to 2.55, p-value=0.01). Higher LBM was associated with better response (OR 2.95, 95% CI 1.29 to 7.17, p-value=0.01) and OS (HR 0.58, 95% CI 0.34 to 0.98, p-value=0.04). However, in multivariate analysis, none of these associations remained significant. Both higher (OR 0.29, 95% CI 0.10 to 0.80, p-value=0.02) and lower visceral to subcutaneous adipose tissue area ratio (VSR) (OR 0.20, 95% CI 0.05 to 0.70, p-value=0.01) were associated with poorer responses, suggesting that a moderate range of VSR may be more beneficial to treatment. Similar to new anthropometric indicators, univariate and multivariate analyses were conducted with high quartile and low quartile as cut-off values for VSR and LBM (Table 2).
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Table 2. Univariate and multivariate analyses assess the association between body composition measures with response, PFS, and OS.
3.6 Interaction between SMI and TATI
Examining potential interactions between muscle composition and adipose composition, we first explored the interaction between SMG and TATI, but no significant interaction was found (Supplementary Tables S4, S5). Despite the significant p-value, when combined with the CI and stratified analysis results, we do not find an interaction between SMG and TATI in our cohort. Subsequently, we examined the interaction between SMI and TATI, finding that the interaction term SMI × TATI was significant for PFS (HR 0.93, 95% CI 0.89 to 0.98, p-value=0.0034) but not for response and OS (Supplementary Table S6). Additionally, we explored whether there was an additive interaction between these variables, but no statistically significant additive interaction effect was found. Subsequently, we controlled SMI and TATI respectively in the multivariate analysis to assess whether the relationship between another indicator and response, PFS, and OS changed (Table 3). We observed that when high SMI was controlled, PFS significantly improved with high TATI (HR 0.39, 95% CI 0.16 to 0.99, p-value=0.046). Conversely, when high TATI was controlled, the negative impact of low SMI on PFS (HR 4.21, 95% CI 1.01 to 17.57, p-value=0.049) and OS (HR 10.96, 95% CI 2.36 to 50.90, p-value=0.0022) became significantly greater. Finally, we employed the KM method to examine survival differences among subgroups with different SMI and TATI combinations. Among all subgroups, the Low SMI + High TATI group exhibited the worst PFS and OS, with the largest difference observed when compared to the High SMI + Medium TATI group (Figure 3).
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Figure 3. The Kaplan-Meier curves of PFS and OS were compared among different SMI and TATI combinations. SMI, skeletal muscle index; TATI, total adipose tissue index; PFS, progression free survival; OS, overall survival.
4 Discussion
To the best of our knowledge, this is the first study providing a comprehensive analysis of the association between body composition, anthropometric indexes, and the prognosis of immunotherapy in patients with ES-SCLC. In the era of chemotherapy, prior studies investigated the relationship between body composition, BMI, and the efficacy and prognosis of small-cell lung cancer (SCLC). While sarcopenia, diagnosed at the L3 levels on CT, has been linked to a poorer prognosis for SCLC (26, 27), the association with BMI remains uncertain. Some studies suggested a negative impact of low BMI on SCLC prognosis (28), while others reported complex and inconclusive associations, with trends toward better prognosis in patients with BMI >28kg/m² and weight loss (WL) ≤5% (29). There is a lack of evidence to suggest a link between WC and its newer variants and the prognosis of SCLC. In the era of immunotherapy, there is limited research, with only one pan-cancer study incorporating three SCLC patients receiving immunotherapy, yielding no conclusive results on BMI (30). Generally, SCLC has received less attention in anthropometric studies. As such the disease is lacking anthropometric biomarkers and presenting a significant clinical challenge.
In numerous preclinical studies, obesity has been correlated with tumor progression, attributed to its role in fostering a chronic inflammatory state and an immunosuppressive tumor immune microenvironment (31). Notably, obesity induces T-cell depletion, as evidenced by increased expression of PD-1, T cell immunoglobulin and mucin domain-3 (TIM-3), and lymphocyte activation gene-3 (LAG-3) in tumor-bearing mice with diet-induced obesity (DIO) (8, 32). However, the advent of immunotherapy has altered this scenario. ICIs counteract T-cell dysfunction by targeting PD-1 or PD-L1. Anti-PD-1 treatment for DIO mice in preclinical studies reversed immunosuppression in the tumor microenvironment (TME), with DIO mice exhibiting enhanced efficacy compared to the control group (33). Some clinical studies also indicated that patients with higher BMI derive more benefits from immunotherapy, termed the “obesity paradox” (6, 8). The debate around the “obesity paradox” centers on the evaluation index of BMI (5). Despite its clinical ubiquity, BMI is a relatively crude measure that inadequately reflects specific body composition. In our study, BMI demonstrated a weak correlation with muscle composition, while skeletal muscle has been established as a prognostic factor in various cancers (34). Recent studies have sought to elucidate the “obesity paradox” using imaging measurements. Young et al. (9), investigating the prognosis of immunotherapy for malignant melanoma, found no association between BMI and clinical outcomes, suggesting that the link between body composition and improved clinical outcomes is modest. Lee et al. (11), on the other hand, proposed that visceral fat might explain the “obesity paradox,” with its prognostic impact dependent on the systemic inflammatory state. Discrepancies between these studies may be attributed to differences in race and cut-off points. Although combining body composition and systemic immune-inflammation index (SII) is popular, establishing a causal relationship between the two remains debatable.
While our study focused on different populations and diseases, our findings generally align with those of Young et al. In univariate analysis and KM curves, the obese group exhibited advantages in terms of PFS and OS, but these advantages did not persist in multivariate analysis. Objectively, we did not identify a clear relationship between high BMI and the prognostic benefits of immunotherapy. Existing anthropometric measures, primarily based on height, weight, and waist circumference, are more closely tied to adipose content and less indicative of skeletal muscle. Among the examined anthropometric measures, BSI emerged as the most promising indicator, reflecting both skeletal muscle and adipose content. BSI was also associated with OS in multivariate analysis, though its efficacy as a biomarker requires further validation. Additionally, our study identified intriguing indicators, such as the association of WWI and LBM with response, potentially linked to the distribution of chemotherapeutic drugs (24). Both higher and lower VSRs were associated with worse responses, suggesting that a moderate VSR may confer better therapeutic benefits. Crucially, our data underscore the significance of the skeletal muscle-adipose tissue interaction. The detrimental effects of sarcopenia are significantly exacerbated in the presence of high adipose, consistent with the understanding that sarcopenic obesity portends worse outcomes (24, 35).This effect was more pronounced in SCLC than what Young et al. observed in malignant melanoma. Given SCLC’s neuroendocrine nature and diverse tumor syndromes, the interaction and crosstalk between tumor and non-tumor tissues merit consideration. Leptin concentration and the leptin/VAT ratio, indicative of adipokine influence, were associated with prolonged PFS in ES-SCLC patients (36). What’s more, anti-growth differentiation factor 15 (GDF-15) combined with anti-PD-1 therapy enhanced anti-PD-1 efficacy (37), as GDF-15 is closely tied to cachexia (38). Skeletal muscle and adipose, functioning as endocrine organs, engage in rich crosstalk in the body (39). Therapies targeting this interaction may not only address metabolic diseases but also enhance immunotherapy efficacy.
Several limitations must be acknowledged in our study. Primarily, being a single-center study introduces potential bias in population characteristics. Notably, our cohort exhibits a significant gender proportion bias, with over 80% of patients being male. The insufficient number of female patients precluded gender-stratified analysis. Moreover, many indicators lack clear-cut criteria, and employing quartiles to establish critical values may be inappropriate. Additional patient characteristics that could impact efficacy, such as immunotherapy-related adverse events and pretreatment weight loss, were not included. The relatively small sample size may affect statistical power, especially during further subgroup analyses. Findings regarding BMI require validation in a larger cohort.
5 Conclusion
In conclusion, our study did not reveal a clear association between BMI and the prognosis of SCLC immunotherapy. However, it reinforced the notion that a high-adipose background amplifies the adverse effects of sarcopenia in the context of SCLC immunotherapy. Notably, BSI emerged as a potential proxy for simple body composition assessment. Given the challenges in visually diagnosing sarcopenic obesity, our study underscores the importance of comprehensive nutritional assessment for cancer patients.
Data availability statement
The original contributions presented in the study are included in the article/Supplementary Material. Further inquiries can be directed to the corresponding authors.
Ethics statement
Approval was acquired from the clinical ethics committee of Zhongnan Hospital of Wuhan University (approval number, 2023163K). The studies were conducted in accordance with the local legislation and institutional requirements. The ethics committee/institutional review board waived the requirement of written informed consent for participation from the participants or the participants’ legal guardians/next of kin because this is a retrospective study, and all data has been de-identified, so there is no harm to the patients.
Author contributions
RF: Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft. LY: Formal analysis, Visualization, Writing – original draft. SX: Data curation, Investigation, Writing – original draft. YX: Methodology, Writing – original draft. TG: Methodology, Writing – original draft. JG: Data curation, Writing – original draft. JZ: Data curation, Writing – original draft. CX: Supervision, Writing – review & editing. ZL: Conceptualization, Supervision, Writing – review & editing.
Funding
The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by Pioneering Oncology Discipline Construction Support Project of Zhongnan Hospital of Wuhan University (grant number XKJS202005) and Key Specialty Construction Project in Clinical Medicine of Zhongnan Hospital of Wuhan University (grant number LC1200000004).
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Supplementary material
The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1439877/full#supplementary-material
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Keywords: small cell lung cancer, immunotherapy, body mass index, sarcopenia, obesity
Citation: Fang R, Yan L, Xu S, Xu Y, Gan T, Gong J, Zhang J, Xie C and Liao Z (2024) Unraveling the obesity paradox in small cell lung cancer immunotherapy: unveiling prognostic insights through body composition analysis. Front. Immunol. 15:1439877. doi: 10.3389/fimmu.2024.1439877
Received: 28 May 2024; Accepted: 07 August 2024;
Published: 26 August 2024.
Edited by:
Arch Mainous, University of Florida, United StatesReviewed by:
Janaki Deepak, University of Maryland, United StatesJoseph Barbi, University at Buffalo, United States
Copyright © 2024 Fang, Yan, Xu, Xu, Gan, Gong, Zhang, Xie and Liao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Zhengkai Liao, zliao@whu.edu.cn; Conghua Xie, chxie_65@whu.edu.cn
†These authors have contributed equally to this work